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Hui Yao¹, Liqun Wang³, Jia Guo¹, Weimin Liu⁴, Jingjing Li¹, Yingxiao Wang², Linhong Deng^1,*, Mingxing Ouyang^1,2,3,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 101-111, 2020, DOI:10.32604/mcb.2020.09595
Abstract Prostate cancer is the most common cancer among men beyond 50 years old, and ranked the second in mortality. The level of Prostate-specific antigen (PSA) in serum has been a routine biomarker for clinical assessment of the cancer development, which is detected mostly by antibody-based immunoassays. The proteolytic activity of PSA also has important functions. Here a genetically encoded biosensor based on fluorescence resonance energy transfer (FRET) technology was developed to measure PSA activity. In vitro assay showed that the biosensor containing a substrate peptide ‘RLSSYYSGAG’ had 400% FRET change in response to 1 µg/ml PSA within 90 min, and… More >

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Phuong-Thao Nguyen-Thi¹, Quoc Phong Le¹, Volker R. Stoldt², Ngoc Quyen Tran^3,4, Anh Tho Le⁵, Khon Huynh^1,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 113-118, 2020, DOI:10.32604/mcb.2020.09643
Abstract Fibrillar fibronectin (FFN) is a biological active form of FN which form linear and branched meshwork around cells and support cellular activities. Previous studies have demonstrated that shear stress can induce cell-free FN fibrillogenesis. In this study, we further examined the effect of shear stress conditions on morphology of formed FFN and preliminarily looked for relationship between FFN’s morphology and cell adhesion. Plasma FN at 50 µg/ml was perfused through channel slides at shear rates of 500 s^-1 or 4000 s^-1. Our results showed that there were four FFN structures formed: (1) FN nodules, (2) fibril in different sizes (3)… More >

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Qi Li^1,2, Ningli Wang³, Zhicheng Liu^1,2, Lin Li^1,2, Zhicheng Liu^1,2, Wenjia Wang^1,2, Xiaoxue Long^1,2, Hongfang Song^1,2,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 119-137, 2020, DOI:10.32604/mcb.2020.09529
Abstract Aim: To investigate the relationship between glaucoma and intraocular pressure (IOP), intracranial pressure (ICP), trans-laminar cribrosa pressure difference (TLCPD), and the newly proposed fractional pressure reserve (FPR). Methods: Ten articles were analyzed by meta-analysis, and subgroup analysis of three factors was conducted. Results: The patients with normal tension glaucoma (NTG) and open-angle glaucoma (OAG) have higher TLCPD and lower ICP than healthy subjects, with obvious heterogeneity. The greater heterogeneity may arise from different ICP measurements and from different countries or regions. FPR performs better than TLCPD in some ways. Conclusion: Both FPR and TLCPD can be used as indicators of… More >

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Xiaozhong Chen^*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 139-153, 2020, DOI:10.32604/mcb.2020.08933
Abstract Existing model registration of individual bones does not have a high certainly of success due to the lack of anatomic semantic. In light of the surface anatomy and functional structure of bones, we hypothesized individual femur models would be aligned through feature points both in geometrical level and in anatomic level, and proposed a hierarchical approach for the rigid registration (HRR) of point cloud models of femur with high resolution. Firstly, a coarse registration between two simplified point cloud models was implemented based on the extraction of geometric feature points (GFPs); and then, according to the anatomic feature points (AFPs)… More >

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