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Compatible Biological Materials Applied to Regenerative Medicine: from the Bench to the Bedside

Submission Deadline: 17 November 2023 (closed)

Guest Editors

Gustavo Fernandes, Lecturer, University of Michigan School of Dentistry, USA
Dr. Gustavo Fernandes is a Clinical Lecturer at the Department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry. He received his DDS degree from the Fluminense Federal University of Niteroi (Rio de Janeiro, Brazil). His M.Sc. Degree in Medical Science and Ph.D. in Dentistry at the Fluminense Federal University (Brazil). Moreover, he also obtained M.Sc. in Dental Medicine at Fernando Pessoa University (Portugal), and his Ph.D. was recognized by the University of Lisbon (Portugal). Dr. Fernandes is a postgraduate in Periodontics and Implant Dentistry and an ITI fellow. Dr. Fernandes has published several scientific articles (more than 80) and currently serves on the editorial board of some important journals and as an ad-hoc reviewer for over 35 different scientific journals. He is interested in clinical procedures, pre-clinical, clinical, and basic research involving bone grafting and biology, tissue repair, material testing, gingival recession, image analysis (histomorphometry and stereology), stem cell research, laser treatment, blood concentrates, dental implants, and oral rehabilitation.

Rodrigo Resende, Specialist, Universidade Federal Fluminense, Brazil
Graduated in Dentistry from the Iguaçu University (2005), Rodrigo Resende was a specialist in Oral and Maxillofacial Surgery and Traumatology from the Gama Filho University / Galeão Air Force Hospital (2008), a specialist in Stomatology from the State University of Rio de Janeiro (2009), Specialist in Implantology from Universidade Federal Fluminense (2020), qualified in Lasers from Universidade de São Paulo - LELO (2018), qualification in nitrous oxide sedation from Orthodontic (2021), Master in Dentistry (2010) and Doctor in Dentistry (2017) from the Fluminense Federal University. He studied an MBA in Strategic Health Management at Universidade Gama Filho (2014) and an MBA in Health Services Management at Universidade Federal Fluminense (2021-2022). Holds BLS course certification by the American Heart Association (2022). He is currently the coordinator of the Laboratory of Animal Experimentation at Universidade Federal Fluminense (LEA/UFF), a member of the Committee on Ethics in the Use of Animals (CEUA) at Universidade Federal Fluminense (Brazil) and Universidade Iguaçu (Brazil) and a member of the Biosafety Committee at the Faculty of Dentistry of Federal Fluminense University. For more than 10 years performs research on biomaterials.


Biocompatibility is one of the mandatory requirements for the use of biomaterials. It refers to the ability of a biomaterial to perform its function without eliciting toxic or harmful effects on biological systems; otherwise, it produces an appropriate host response. It is considered a key concept in understanding the host response to biomaterials. Currently, the biocompatibility concept includes bio-inertia, biofunctionality, and biostability. High biocompatibility and functional properties are highly desirable for new biomaterials. The physical, chemical, mechanical, and structural properties of biomaterials and their interaction with the biological environment or even the assessment methodology can influence biocompatibility.


The biological evaluation of biomaterials includes a broad spectrum of in vitro and in vivo tests related to cytocompatibility, genotoxicity, sensitization, irritation, acute and chronic toxicity, hemocompatibility, reproductive and developmental toxicity, carcinogenicity, implantation, and degradation as specified in different international standards, such as cell biomaterial interactions, and in vivo assessment, including the foreign body reaction (FBR). Nevertheless, the recent interdisciplinary tissue engineering approaches that combine the principles of material and regenerative sciences have emerged with a new definition for biocompatibility is the ability of a tissue engineering scaffold or matrix to support the appropriate cellular activity, including the facilitation of molecular and mechanical signaling systems to optimize tissue regeneration without eliciting any undesirable local or systemic response in the eventual host.


Then, this special edition focuses on the development, design, characterization, biological safety results of biobased-materials biocompatibility, which can be tested, prepared, and applied in vitro and in vivo.


Biomaterials;regenerative medicine; reconstructions; treatment; biocompatible.

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