Home / Journals / MCB / Vol.16, Suppl.2, 2019
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  • Open AccessOpen Access

    ABSTRACT

    The Rate of Fluid Shear Stress is a Potent Regulator for Lineage Commitment of Mesenchymal Stem Cells Through Modulating [Ca2+]i, F-actin and Lamin A

    Danyang Yue1, Yijuan Fan1, Juan Lu1, Mengxue Zhang1, Jin Zhou1, Yuying Bai1, Jun Pan1,*
    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 144-144, 2019, DOI:10.32604/mcb.2019.07084
    Abstract Mesenchymal Stem Cells (MSCs) are recruited to the musculoskeletal system following trauma [1] or chemicals stimulation [2]. The regulation of their differentiation into either bone or cartilage cells is a key question. The fluid shear stress (FSS) is of pivotal importance to the development, function and even the repair of all tissues in the musculoskeletal system [3]. We previously found that MSCs are sensitive enough to distinguish a slight change of FSS stimulation during their differentiation commitment to bone or cartilage cells, and the internal mechanisms. In detail, MSCs were exposed to laminar FSS linearly increased from 0 to 10… More >

  • Open AccessOpen Access

    ABSTRACT

    The Mechanical Mechanism of Cortical Folding on 3D Cerebral Organoids

    Zongkun Hou1, Shilei Hao1, Bochu Wang1,*
    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 145-145, 2019, DOI:10.32604/mcb.2019.07077
    Abstract An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. The cortical folding has been implicated in neurodevelopmental disorders and yet its origins remain unknown. In vitro culture of 3D cerebral organoids from human pluripotent stem cells has been used to study the fundamental mechanisms of mammalian neurodevelopment and characteristics of human brain development. Here, we explores the mechanism of boundary limitation on the formation of gyri and sulci through the self-organization of human brain organoids. The structure of cerebral organoids was analyzed by morphology observation, pathology and immunofluorescence. The different… More >

  • Open AccessOpen Access

    ABSTRACT

    Microspheres Modified with the Heparin Increasing the Length of Molecular Linker to Better Capture the Endotoxin

    Qi Dang1, Chun-Gong Li1, Xin-Xin Jin1, Ya-Jin Zhao1, Xiang Wang1,*
    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 146-146, 2019, DOI:10.32604/mcb.2019.07074
    Abstract Endotoxin is a a very powerful and toxic inflammatory stimulator usually leading to the sepsis occurred. In order to remove endotoxin better through hemoperfusion, it is a pretty choice to increase the length of molecular linker on adsorbents. In this study, we chose the heparin as a molecular linker because of its being anticoagulant linear polysaccharide. Heparin as a linker was covalently immobilized on the chloromethylated polystyrene microspheres (Ps) and then connected with L-phenylalanine (Phe) forming the Ps-Hep-Phe structure to adsorbed endotoxin better. The property of microspheres was characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, zeta potential and… More >

  • Open AccessOpen Access

    ABSTRACT

    Rationally Designed Synthetic Protein Hydrogels with Predictable and Controllable Mechanical Properties

    Ying Li1, Bin Xue2, Wenxu Sun2, Junhua Wu2, Wenting Yu2, Meng Qin2, Wei Wang2, Yi Cao2,*
    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 147-147, 2019, DOI:10.32604/mcb.2019.07027
    Abstract A key challenge in biomaterials research is to produce synthetic hydrogels that can replicate the diverse mechanical properties of the naturally occurring tissues for various biomedical applications, including tissue engineering, stem cell and cancer research, cell therapy, and immunomodulation. However, currently, the methods that can be used to control the mechanical properties of hydrogels are very limited and are mainly focused only on the elasticity of hydrogels. In this work, combining single molecule force spectroscopy, protein engineering and theoretical modeling, we show that synthetic protein hydrogels with predictable mechanical properties can be rationally designed using protein building blocks with known… More >

  • Open AccessOpen Access

    ABSTRACT

    The Effect of the Elongation of the Proximal Aorta on the Estimation of Aortic Wall Distensibility

    Stamatia Pagoulatou1,*, Mauro Ferraro1, Bram Trachet1,2, Georgios Rovas1, Vasiliki Bikia1, Dionysios Adamopoulos3, Lindsey Crowe3, Jean-Paul Vallée3, Nikolaos Stergiopulos1
    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 148-149, 2019, DOI:10.32604/mcb.2019.07346
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    ABSTRACT

    Investigation on Energy Characteristic of RBCs Deformability: A Quantitative Analysis of Extending and Retracting Curves Based on AFM

    Dong Chen1, Xiang Wang1,*, Fuzhou Tang2, Yajin Zhao1
    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 150-150, 2019, DOI:10.32604/mcb.2019.07071
    Abstract Deformability is a fundamental property of the cells and tissues of living organisms, which is commonly detected to indicate the state of the cells. And the cell deformability usually depends on the methods that we used, which is easy to be confused. The present research is designed to explore the energy characteristic of red blood cell deformability, based on a quantitative analysis of extending-retracting curves acquired from atomic force microscopy. ATP-depleted red blood cells are prepared by treatment with free-glucose Ringer solution. Our results clearly show that the Youngs’ modulus of erythrocyte is closely depended on the concentration of intracellular… More >

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