Molecular & Cellular Biomechanics

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ISSN: 1556-5297 (print)
ISSN: 1556-5300 (online) Publication Frequency: Quarterly

About the Journal

The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications. This journal will encourage the exchange of ideas that may be seminal, or hold promise to stimulate others to new findings.

Indexing and Abstracting

Applied Mechanics Reviews; BIOBASE (Elsevier); BIOSIS Preview-Web of Science (Clarivate Analytics); Cambridge Scientific Abstracts-Proquest; Ei Compendex/Engineering Village (Elsevier); EMBASE (Elsevier); GEOBASE (Elsevier); INSPEC (IET); Science Navigator; Scopus (Elsevier): Citescore 2018: 0.64; SNIP (Source Normalized Impact per Paper 2018): 0.528; World Textiles and Scopus; Zentralblatt fur Mathematik; Portico, etc...

Current Issue - Vol.17, No.4, 2020 Most Viewed

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ARTICLE
The Effect of Continued Training with Crocin on Apoptosis Markers in Liver Tissue of High Fat Diet Induced Diabetic Rats
Zahra Alimanesh¹, Zeynab Alimanesh¹, Fatemeh Davari², Saeedeh Shadmehri³, Mozhgan Ahmadi³, Seyed Ali Hosseini⁴, Sepideh Dolati^5,*, Alemeh Hariri Far⁶
Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 155-163, 2020, DOI:10.32604/mcb.2020.011532
Abstract Diabetes mellitus (DM) disease can affect process of apoptosis by increasing oxidative stress, nevertheless exercise and crocin can improve apoptosis; therefore present study aimed to investigate the effect of continued training with crocin on apoptosis markers in liver tissue of diabetic rats. In this experimental study 32 diabetic rats based on fasting glucose divided into four groups of eight rats including: 1) sham, 2) training, 3) crocin, and 4) training with crocin also for investigate the effect of DM induction on apoptosis markers, eight healthy rats assigned in healthy control group. During eight weeks groups 2 and 4 ran 60… More
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ARTICLE
Application of Dual Modality Contrast Agent Combined with Multi-Scale Representation in Ultrasound-Magnetic Resonance Imaging Registration Scheme
Mo Hou^1,*, Weiyu Kevin Chiang^2,*, Weiqiang Hong¹, Maoyun Yang¹, Wenhua Yu^3,4
Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 165-178, 2020, DOI:10.32604/mcb.2020.010805
Abstract To achieve the image registration/fusion and perfect the quality of the integration, with dual modality contrast agent (DMCA), a novel multi-scale representation registration method between ultrasound imaging (US) and magnetic resonance imaging (MRI) is presented in the paper, and how DMCA influence on registration accuracy is chiefly discussed. Owing to US’s intense speckle noise, it is a tremendous challenge to register US with any other modality images. How to improve the algorithms for US processing has become the bottleneck, and in the short term it is difficult to have a breakthrough. In that case, DMCA is employed in both US… More
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ARTICLE
Dynamic Resistance Parameters of Arm Stroke during Swimming
Bin Wang¹, Dayong Li², Yuxin Qin^3,*
Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 179-188, 2020, DOI:10.32604/mcb.2020.011050
Abstract Swimming, as a sport beneficial to body and mind, also has a place in international sports. For swimmers and coaches, it is always the most important to improve the propulsion and reduce the resistance during swimming. This paper briefly introduced the resistance of human body in swimming, described the dynamic resistance of human body in arm stroke, and then introduced the principle of micro disturbance method which was used for measuring the dynamic resistance in swimming. Finally, ten swimmers from school team and ten beginners were tested for the dynamic resistance in freestyle, backstroke and breaststroke when they swam with… More
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ARTICLE
The Kinematics and Surface Electromyography Characteristics of Round Kick of Martial Arts Athletes
Xin Wang^*
Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 189-198, 2020, DOI:10.32604/mcb.2020.011236
Abstract In order to improve the level of athletes, modern scientific and technological means can be used to understand the characteristics and rules of movement. This study mainly analyzed the whip leg technique of Sanda athletes. Taking ten athletes as an example, the kinematics and surface electromyography (sEMG) data of them were measured, calculated and sorted out when they were doing the action of round kick. The results showed that the movement completion time of the first-level athletes was shorter, 0.34 ± 0.33 s. In the stage of turning hip and hitting, the angle of hip joint increased significantly. In the… More
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ARTICLE
Toxicity Evaluation of Geniposide on MCF-7 Cancer Cells
Kena Lv¹, Shuangshuang Zheng², Xiangqin Li¹, Yi Nie^2,3,*, Tianqing Liu¹, Kedong Song^1,*
Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 199-204, 2020, DOI:10.32604/mcb.2020.011811
Abstract As one of the adjuvant treatments for cancer treatment, traditional Chinese medicine treatment has a wide range of cancer treatments, such as preventing metastasis and relapse, improving the efficacy of radiotherapy and chemotherapy, reducing the side effects of chemotherapy, improving body function, extending life and improving the life quality. Geniposide (GEN) is a bioactive substance extracted from the fruit of gardenia. In recent years, it has attracted attention due to its anti-tumor effect. In this study, we aimed to investigate whether GEN could inhibit the proliferation of human breast cancer cells (MCF-7) and promote its apoptosis. The half-inhibitory concentration (IC50)… More
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ARTICLE
Kinematic and Dynamic Characteristics of Pulsating Flow in 180^o Tube
Tin-Kan Hung^1,*, Ruei-Hung Kuo², Cheng-Hsien Chiang³
Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 19-24, 2020, DOI:10.32604/mcb.2019.07817
Abstract Kinematic and dynamic characteristics of pulsating flow in a model of human aortic arch are obtained by a computational analysis. Three-dimensional flow processes are summarized by pressure distributions on the symmetric plane together with velocity and pressure contours on a few cross sections for systolic acceleration and deceleration. Without considering the effects of aortic tapering and the carotid arteries, the development of tubular boundary layer with centrifugal forces and pulsation are also analyzed for flow separation and backflow during systolic deceleration. More
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Finite Element Modelling Predicts Large Accommodation Induced Optic Nerve Head Deformations
Xiaofei Wang^1,2,*, Yubo Fan^1,2
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 112-112, 2019, DOI:10.32604/mcb.2019.07053
Abstract Accommodation is the ability of the eye to adjust its lens thickness to alter the refractive power through the contraction of ciliary muscles. The loss of accommodation ability due to aging leads to presbyopia, a condition in which the eye is unable to focus on near objects. Glaucoma is a disease that vision is impaired due to damage of the retinal ganglion cell at the optic nerve head (ONH) region, which is the leading cause of irreversible blindness worldwide. The biomechanical theory of glaucoma suggests that the deformations of ONH tissues could (directly or indirectly) drive retinal ganglion cell death.… More
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Molecular Mechanoimmunology
Cheng Zhu^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 11-11, 2019, DOI:10.32604/mcb.2019.08411
Abstract The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of mechanical forces on specific immunoreceptor–ligand bonds, which are transmitted across the cell membrane, potentially inducing mechanotransduction. As mechanobiology intersects with immunology, the interest to explore how immune cells sense, respond and adapt to their mechanical environment is rapidly growing. In this talk, I will review recent advances in the emerging field of… More
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Multifrequency Microwave Imaging for Brain Stroke Detection
Lulu Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 125-125, 2019, DOI:10.32604/mcb.2019.07101
Abstract Early diagnosis of stroke with timely treatment could reduce adult permanent disability significantly [1]. Conventional medical imaging tools such as X-ray, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used for diagnosis of brain disease. However, each of these methods has some limitations. X-ray imaging produces harmful radiation to the human body and challenging to identify early-stage abnormal tissue due to the relatively small dielectric proprieties contrast between the healthy tissue and abnormal tissue at X-ray frequencies [2]. PET provides useful information about soft tissues, but it is expensive and produces poor… More
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Engineering Zap70 Biosensor Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy
Longwei Liu¹, Praopim Limsakul¹, Shaoying (Kathy) Lu¹, Peter Yingxiao Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 82-82, 2019, DOI:10.32604/mcb.2019.07360
Abstract Genetically-encoded biosensors based on Fluorescence Resonance Energy Transfer (FRET biosensors) have been widely used to dynamically track the activity of Protein Tyrosine Kinases (PTKs) in living cells because of their sensitive ratiometric fluorescence readout, high spatiotemporal resolution. However, the limitation in sensitivity, specificity, and dynamic range of these biosensors have hindered their broader applications, and there was a lack of efficient ways to optimize FRET biosensors. Here we established a rapid, systematic and universal approach for FRET biosensor optimization through directed evolution which involves generating genetic diversity and screening for protein variants with desired properties at the same time and… More
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Mechano-Electric Feedback and Arrhythmogenic Current Generation in A Computational Model of Coupled Myocytes
Viviane Timmermann¹, Kevin Vincent², Joakim Sundnes¹, Andrew D. McCulloch^2,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 133-133, 2019, DOI:10.32604/mcb.2019.07311
Abstract Heterogeneous mechanical dyskinesis has been implicated in arrhythmogenic phenotypes. Strain-induced perturbations to cardiomyocyte electrophysiology (EP) may trigger arrhythmias via a variety of mechano-electric feedback (MEF) mechanisms. While the role of stretch-activated ionic currents (SACs) has been investigated intensively using computational models, experimental studies have shown that mechanical strain can also trigger intra- and inter-cellular calcium waves. To investigate whether the inherent strain dependence of myofilament calcium affinity may promote arrhythmogenic intra- and inter-cellular calcium waves under conditions of pathologic mechanical heterogeneity, we coupled a mathematical model of excitation-contraction coupling (ECC) in rabbit ventricular myocytes to a model of myofilament activation… More
Views:3506 Downloads:733 Download PDF