Molecular & Cellular Biomechanics

ISSN: 1556-5297 (print)
ISSN: 1556-5300 (online) Publication Frequency: Quarterly

About the Journal

The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications. This journal will encourage the exchange of ideas that may be seminal, or hold promise to stimulate others to new findings.

Indexing and Abstracting

Applied Mechanics Reviews; BIOBASE (Elsevier); BIOSIS Preview-Web of Science (Clarivate Analytics); Cambridge Scientific Abstracts-Proquest; Ei Compendex/Engineering Village (Elsevier); EMBASE (Elsevier); GEOBASE (Elsevier); INSPEC (IET); Science Navigator; Scopus (Elsevier): Citescore 2020: 0.7; SNIP (Source Normalized Impact per Paper 2020): 0.145; World Textiles and Scopus; Zentralblatt fur Mathematik; Portico, etc...

Current Issue - Vol.18, No.3, 2021 Most Viewed

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ARTICLE
Impact of Coronary Artery Curvature on the Longitudinal Stent Foreshortening: Real-World Observations
Yang Li^1,#, Runxin Fang^2,#, Renyun Wang¹, Qiming Dai¹, Zhiyong Li^2,*, Genshan Ma¹
Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 119-122, 2021, DOI:10.32604/mcb.2021.017503
Abstract Longitudinal stent foreshortening is a known phenomenon, however, the impact of coronary artery curvature on longitudinal stent foreshortening remains unclear. The aim of this study is to determine the impact of coronary artery curvature on the longitudinal stent foreshortening in the real-world scenarios. A total of 86 consecutive patients underwent coronary stent implantation were included in the present study. The degree of coronary artery curvature was defined as the length of the coronary artery curvature divided by the straight length. Longitudinal stent foreshortening was defined as the stent length after implantation divided by the stent length before implantation. The mean… More
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ARTICLE
Surface Topography Assessments of Spine Shape Change within the Day in Healthy Male Adults
Jianming Lu^1,*, Liangliang Xiang², Huw Wiltshire³
Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 123-129, 2021, DOI:10.32604/mcb.2021.015993
Abstract Surface topography is a no-invasive, radiation-free method that can measure sufficient surface spine parameters by the structured back surface scan and a precise anatomical landmarks recognition. The purpose of the present study was to measure the spine shape parameter changes within the day via the DIERS Formetric 4D analysis system. Ten male healthy volunteers were recruited to participate in the experiment. All participants were sedentary people with the average sitting time during study or work t ≥ 8 h and without any back disease in the past six months. Data were analyzed by one-way ANOVA, which set time points within… More
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ARTICLE
Study of Hepatocytes Polyploidization Peculiarities in Cholestatic Liver of Adult Rats
Salome Kiparoidze^1,*, Nino Karumidze², Ekaterine Bakuradze¹, Irina Modebadze¹, Levan Rusishvili¹, Dimitri Kordzaia², Diana Dzidziguri¹
Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 131-138, 2021, DOI:10.32604/mcb.2021.015596
Abstract According to the literature, different mechanisms and kinetics proceeding of regenerative growth has been established using the basic models of liver regeneration (after resection or chemically induced). Hence, in order to determine general regularities of the adaptive-compensatory processes in various pathological conditions, the processes taking place in the cholestatic liver of adult white rats during the first four days after common bile duct ligation have been studied. It has been shown that in cholestatic liver, compensatory-adaptive processes take place with different kinetics compared to those after resection. In particular, in response to the increased functional load caused by destructive processes… More
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ARTICLE
Comparison of Detection and Classification of Hard Exudates Using Artificial Neural System vs. SVM Radial Basis Function in Diabetic Retinopathy
V. Sudha^1,*, T. R. Ganesh Babu², N. Vikram¹, R. Raja²
Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 139-145, 2021, DOI:10.32604/mcb.2021.016056
Abstract Diabetic Retinopathy (DR) is a disease that occurs in the eye which results in blindness as it passes to proliferative stage. Diabetes can significantly result in symptoms like blurring of vision, kidney failure, nervous damage. Hence it has become necessary to identify retinal damage that occurs in diabetic eye due to raised glucose level in its initial stage itself. Hence automated detection of anamoly has become very essential. The appearance of crimson and yellow lesions is considered as the earliest symptoms of DR which are called as hemorrhages and exudates. If DR is analysed at initial stage, blindness does not… More
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ARTICLE
Analysis of the Movement Track of Top Spinning Ball and Biomechanics in the Process of Hitting Tennis Ball
Xia Xie^*
Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 147-156, 2021, DOI:10.32604/mcb.2021.016246
Abstract The aim of this study is to analyze the movement track of top spinning tennis ball and the biomechanics characteristics of tennis players. This study took ten tennis players as an example. The hitting process of the top spinning ball was captured by two PULNIX high-speed cameras. The images were processed by APAS motion analysis system. The results showed that the top spinning ball moved forward while rotating in the hitting process and showed a large attack force after rebounding from the land. In biomechanics, A and B had larger angles of upper limb joints and larger joint speed. The… More
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ARTICLE
Kinematic and Dynamic Characteristics of Pulsating Flow in 180^o Tube
Tin-Kan Hung^1,*, Ruei-Hung Kuo², Cheng-Hsien Chiang³
Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 19-24, 2020, DOI:10.32604/mcb.2019.07817
Abstract Kinematic and dynamic characteristics of pulsating flow in a model of human aortic arch are obtained by a computational analysis. Three-dimensional flow processes are summarized by pressure distributions on the symmetric plane together with velocity and pressure contours on a few cross sections for systolic acceleration and deceleration. Without considering the effects of aortic tapering and the carotid arteries, the development of tubular boundary layer with centrifugal forces and pulsation are also analyzed for flow separation and backflow during systolic deceleration. More
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ABSTRACT
Finite Element Modelling Predicts Large Accommodation Induced Optic Nerve Head Deformations
Xiaofei Wang^1,2,*, Yubo Fan^1,2
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 112-112, 2019, DOI:10.32604/mcb.2019.07053
Abstract Accommodation is the ability of the eye to adjust its lens thickness to alter the refractive power through the contraction of ciliary muscles. The loss of accommodation ability due to aging leads to presbyopia, a condition in which the eye is unable to focus on near objects. Glaucoma is a disease that vision is impaired due to damage of the retinal ganglion cell at the optic nerve head (ONH) region, which is the leading cause of irreversible blindness worldwide. The biomechanical theory of glaucoma suggests that the deformations of ONH tissues could (directly or indirectly) drive retinal ganglion cell death.… More
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Molecular Mechanoimmunology
Cheng Zhu^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 11-11, 2019, DOI:10.32604/mcb.2019.08411
Abstract The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of mechanical forces on specific immunoreceptor–ligand bonds, which are transmitted across the cell membrane, potentially inducing mechanotransduction. As mechanobiology intersects with immunology, the interest to explore how immune cells sense, respond and adapt to their mechanical environment is rapidly growing. In this talk, I will review recent advances in the emerging field of… More
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Engineering Zap70 Biosensor Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy
Longwei Liu¹, Praopim Limsakul¹, Shaoying (Kathy) Lu¹, Peter Yingxiao Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 82-82, 2019, DOI:10.32604/mcb.2019.07360
Abstract Genetically-encoded biosensors based on Fluorescence Resonance Energy Transfer (FRET biosensors) have been widely used to dynamically track the activity of Protein Tyrosine Kinases (PTKs) in living cells because of their sensitive ratiometric fluorescence readout, high spatiotemporal resolution. However, the limitation in sensitivity, specificity, and dynamic range of these biosensors have hindered their broader applications, and there was a lack of efficient ways to optimize FRET biosensors. Here we established a rapid, systematic and universal approach for FRET biosensor optimization through directed evolution which involves generating genetic diversity and screening for protein variants with desired properties at the same time and… More
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Multifrequency Microwave Imaging for Brain Stroke Detection
Lulu Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 125-125, 2019, DOI:10.32604/mcb.2019.07101
Abstract Early diagnosis of stroke with timely treatment could reduce adult permanent disability significantly [1]. Conventional medical imaging tools such as X-ray, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used for diagnosis of brain disease. However, each of these methods has some limitations. X-ray imaging produces harmful radiation to the human body and challenging to identify early-stage abnormal tissue due to the relatively small dielectric proprieties contrast between the healthy tissue and abnormal tissue at X-ray frequencies [2]. PET provides useful information about soft tissues, but it is expensive and produces poor… More
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ABSTRACT
Mechano-Electric Feedback and Arrhythmogenic Current Generation in A Computational Model of Coupled Myocytes
Viviane Timmermann¹, Kevin Vincent², Joakim Sundnes¹, Andrew D. McCulloch^2,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 133-133, 2019, DOI:10.32604/mcb.2019.07311
Abstract Heterogeneous mechanical dyskinesis has been implicated in arrhythmogenic phenotypes. Strain-induced perturbations to cardiomyocyte electrophysiology (EP) may trigger arrhythmias via a variety of mechano-electric feedback (MEF) mechanisms. While the role of stretch-activated ionic currents (SACs) has been investigated intensively using computational models, experimental studies have shown that mechanical strain can also trigger intra- and inter-cellular calcium waves. To investigate whether the inherent strain dependence of myofilament calcium affinity may promote arrhythmogenic intra- and inter-cellular calcium waves under conditions of pathologic mechanical heterogeneity, we coupled a mathematical model of excitation-contraction coupling (ECC) in rabbit ventricular myocytes to a model of myofilament activation… More
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