Molecular & Cellular Biomechanics

ISSN: 1556-5297 (print)
ISSN: 1556-5300 (online) Publication Frequency: Quarterly

About the Journal

The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications. This journal will encourage the exchange of ideas that may be seminal, or hold promise to stimulate others to new findings.

Indexing and Abstracting

Applied Mechanics Reviews; BIOBASE (Elsevier); BIOSIS Preview-Web of Science (Clarivate Analytics); Cambridge Scientific Abstracts-Proquest; Ei Compendex/Engineering Village (Elsevier); EMBASE (Elsevier); GEOBASE (Elsevier); INSPEC (IET); Science Navigator; Scopus (Elsevier): Citescore 2020: 0.7; SNIP (Source Normalized Impact per Paper 2020): 0.145; World Textiles and Scopus; Zentralblatt fur Mathematik; Portico, etc...

Current Issue - Vol.18, No.2, 2021 Most Viewed

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REVIEW
Effect of Mechanical Forces on the Behavior of Dental Stem Cells: A Scoping Review of In-Vitro Studies
Maryam Rezai Rad¹, Sadra Mohaghegh², Farnaz Kouhestani³, Saeed Reza Motamedian^4,*
Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 51-67, 2021, DOI:10.32604/mcb.2021.015136
Abstract This article is a scoping review of the studies that assessed the effect of mechanical forces on the behavior of dental stem cells (DSCs). PubMed and Scopus searches were done for in-vitro studies evaluating the effect of tension, hydrostatic pressure (i.e., the pressure applied through an incompressible fluid), compression, simulated microgravity, and vibration on DSCs. The following factors were analyzed: osteogenic/odontogenic differentiation, proliferation, adhesion and migration. Articles were reviewed according to the Preferred Reporting Items for Systematic Reviews extension for scoping reviews (PRISMA-ScR) guideline. Included studies were evaluated based on the modified Consolidated Standards of Reporting Trials (CONSORT). A total… More
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ARTICLE
Determination of Cup to Disc Ratio Using Unsupervised Machine Learning Techniques for Glaucoma Detection
R. Praveena^*, T. R. GaneshBabu
Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 69-86, 2021, DOI:10.32604/mcb.2021.014622
Abstract The cup nerve head, optic cup, optic disc ratio and neural rim configuration are observed as important for detecting glaucoma at an early stage in clinical practice. The main clinical indicator of glaucoma optic cup to disc ratio is currently determined manually by limiting the mass screening was potential. This paper proposes the following methods for an automatic cup to disc ratio determination. In the first part of the work, fundus image of the optic disc region is considered. Clustering means K is used automatically to extract the optic disc whereas K-value is automatically selected by algorithm called hill climbing.… More
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ARTICLE
Motion Features of Legs in Volleyball Block Jump Based on Biomechanical Analysis
Zilin Li, Junjiang Wang, Yan Yang^*
Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 87-97, 2021, DOI:10.32604/mcb.2021.014731
Abstract Blocking technology is one of the most important means to obtain score in volleyball, which has a great influence on the victory of the game. In this study, the vertical jump was analyzed to understand the movement characteristics of legs during training time. The kinematics and dynamics data of the legs of 10 volleyball players after training for 0 h, 0.5 h, 1 h and 2 h were studied by using an infrared light point motion capture system and force measuring platform. The results showed that the joint angles of the players who had 1 h and 2 h of… More
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ARTICLE
Study on the Effect of PNF Method on the Flexibility and Strength Quality of Stretching Muscles of Shoulder Joints of Swimmers
Boqing Li, Xiaolong Bai, Yongli Zhu^*
Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 99-105, 2021, DOI:10.32604/mcb.2021.014748
Abstract In the process of swimming, the shoulder joint will be damaged when the arm is stroking. To reduce the injury of shoulder joints and improve the speed of stroke, it is necessary to train the flexibility of shoulder joints. This paper briefly introduced the concept of shoulder joint and flexibility and then explained the traditional stretching training method and proprioceptive neuromuscular facilitation (PNF) stretching method. Then, taking 20 college team swimmers of Yunnan University as the subjects, the comparative experiment of the traditional and PNF stretching methods was carried out. The results showed that the shoulder rotation index of the… More
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ARTICLE
The Differences in Lower Extremity Joints Energy Dissipation Strategy during Landing between Athletes with Symptomatic Patellar Tendinopathy (PT) and without Patellar Tendinopathy (UPT)
Datao Xu¹, Zhenghui Lu¹, Siqin Shen², Gusztáv Fekete², Ukadike C. Ugbolue³, Yaodong Gu^1,*
Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 107-118, 2021, DOI:10.32604/mcb.2021.015453
Abstract Patellar tendinopathy is a clinical symptom of patellar tendons characterized by local pain in the front of the knee joint. It is common among basketball and volleyball players. Patients with patellar tendinopathy may exhibit different landing strategies during landing compared to healthy individuals. The purpose of this study was to compare the differences in lower limb joint energy dissipation (eccentric work) values for the symptomatic patellar tendinopathy (PT) athletes and no patellar tendinopathy (UPT) athletes during single-leg landing. A total of 26 (PT: 13, UPT:13) semi-professional male basketball and volleyball player’s kinetic data were collected during the landing phases. Joint… More
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ARTICLE
Kinematic and Dynamic Characteristics of Pulsating Flow in 180^o Tube
Tin-Kan Hung^1,*, Ruei-Hung Kuo², Cheng-Hsien Chiang³
Molecular & Cellular Biomechanics, Vol.17, No.1, pp. 19-24, 2020, DOI:10.32604/mcb.2019.07817
Abstract Kinematic and dynamic characteristics of pulsating flow in a model of human aortic arch are obtained by a computational analysis. Three-dimensional flow processes are summarized by pressure distributions on the symmetric plane together with velocity and pressure contours on a few cross sections for systolic acceleration and deceleration. Without considering the effects of aortic tapering and the carotid arteries, the development of tubular boundary layer with centrifugal forces and pulsation are also analyzed for flow separation and backflow during systolic deceleration. More
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ABSTRACT
Finite Element Modelling Predicts Large Accommodation Induced Optic Nerve Head Deformations
Xiaofei Wang^1,2,*, Yubo Fan^1,2
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 112-112, 2019, DOI:10.32604/mcb.2019.07053
Abstract Accommodation is the ability of the eye to adjust its lens thickness to alter the refractive power through the contraction of ciliary muscles. The loss of accommodation ability due to aging leads to presbyopia, a condition in which the eye is unable to focus on near objects. Glaucoma is a disease that vision is impaired due to damage of the retinal ganglion cell at the optic nerve head (ONH) region, which is the leading cause of irreversible blindness worldwide. The biomechanical theory of glaucoma suggests that the deformations of ONH tissues could (directly or indirectly) drive retinal ganglion cell death.… More
Views:4157 Downloads:1251 Download PDF

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ABSTRACT
Molecular Mechanoimmunology
Cheng Zhu^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 11-11, 2019, DOI:10.32604/mcb.2019.08411
Abstract The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of mechanical forces on specific immunoreceptor–ligand bonds, which are transmitted across the cell membrane, potentially inducing mechanotransduction. As mechanobiology intersects with immunology, the interest to explore how immune cells sense, respond and adapt to their mechanical environment is rapidly growing. In this talk, I will review recent advances in the emerging field of… More
Views:4109 Downloads:1204 Download PDF

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ABSTRACT
Multifrequency Microwave Imaging for Brain Stroke Detection
Lulu Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 125-125, 2019, DOI:10.32604/mcb.2019.07101
Abstract Early diagnosis of stroke with timely treatment could reduce adult permanent disability significantly [1]. Conventional medical imaging tools such as X-ray, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used for diagnosis of brain disease. However, each of these methods has some limitations. X-ray imaging produces harmful radiation to the human body and challenging to identify early-stage abnormal tissue due to the relatively small dielectric proprieties contrast between the healthy tissue and abnormal tissue at X-ray frequencies [2]. PET provides useful information about soft tissues, but it is expensive and produces poor… More
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ABSTRACT
Engineering Zap70 Biosensor Through Directed Evolution for Applications in Single-Cell Imaging and Immunotherapy
Longwei Liu¹, Praopim Limsakul¹, Shaoying (Kathy) Lu¹, Peter Yingxiao Wang^1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 82-82, 2019, DOI:10.32604/mcb.2019.07360
Abstract Genetically-encoded biosensors based on Fluorescence Resonance Energy Transfer (FRET biosensors) have been widely used to dynamically track the activity of Protein Tyrosine Kinases (PTKs) in living cells because of their sensitive ratiometric fluorescence readout, high spatiotemporal resolution. However, the limitation in sensitivity, specificity, and dynamic range of these biosensors have hindered their broader applications, and there was a lack of efficient ways to optimize FRET biosensors. Here we established a rapid, systematic and universal approach for FRET biosensor optimization through directed evolution which involves generating genetic diversity and screening for protein variants with desired properties at the same time and… More
Views:4009 Downloads:1187 Download PDF

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ABSTRACT
Mechano-Electric Feedback and Arrhythmogenic Current Generation in A Computational Model of Coupled Myocytes
Viviane Timmermann¹, Kevin Vincent², Joakim Sundnes¹, Andrew D. McCulloch^2,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 133-133, 2019, DOI:10.32604/mcb.2019.07311
Abstract Heterogeneous mechanical dyskinesis has been implicated in arrhythmogenic phenotypes. Strain-induced perturbations to cardiomyocyte electrophysiology (EP) may trigger arrhythmias via a variety of mechano-electric feedback (MEF) mechanisms. While the role of stretch-activated ionic currents (SACs) has been investigated intensively using computational models, experimental studies have shown that mechanical strain can also trigger intra- and inter-cellular calcium waves. To investigate whether the inherent strain dependence of myofilament calcium affinity may promote arrhythmogenic intra- and inter-cellular calcium waves under conditions of pathologic mechanical heterogeneity, we coupled a mathematical model of excitation-contraction coupling (ECC) in rabbit ventricular myocytes to a model of myofilament activation… More
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