Special lssues

Therapeutic Efficiency of Phyto-Molecules

Submission Deadline: 02 February 2022 (closed)

Guest Editors

Dr. Kandasamy Saravanakumar, Kangwon National University, Korea
Dr. Myeong-Hyeon Wang, Kangwon National University, Korea
Dr. Veeraraghavan Vishnu Priya, Saveetha University, India


The new viral, bacterial and fungal pathogens are currently developing resistance to several available drugs. Newly discovered drugs like compounds are more virulent to inhibiting the viral or microbial pathogens related diseases and cancer cells in vitro but is not successful in the host due to less stability and inability to targeting the pathogenic location. Therefore, discovery of the novel drugs is important and by the way development of novel strategies to enhance its therapeutic efficiency also is essential. Therefore, proper understating of the new compounds characteristics and its chemistry can enable us to develop the novel drug carrier system to improve its therapeutic efficiency. Hence, this special issue in aims to focusing the isolation of novel metabolites from the plant resources and increasing its stability and targeted delivery by using the nano-drug carrier delivery system (nDDS). Further evaluating the therapeutic efficiency of drug loaded nDDS in host level by animal experiments, including the following but not limited in scope to:

1. Bioactive compounds

2. Methods in isolation of novel compounds

3. Chromatography techniques in compounds purification

4. nDDS for improving therapeutic efficiency of natural compounds  

5. Nanotechnology advances for medicinal natural product research


Medicinal Plant Extracts, Antioxidants, Enzyme Inhibitors, Nanoparticles from Natural Products

Published Papers

  • Open Access


    Rapid Analysis of Four Alkaloids in Uncaria rhynchophylla by Core-Shell Column HPLC and Quantitative Analysis of Multi-Components by Single Marker (QAMS)

    Kesheng Lin, Jiawen Zhou, Lijuan Han, Ning Li
    Phyton-International Journal of Experimental Botany, Vol.92, No.1, pp. 285-296, 2023, DOI:10.32604/phyton.2022.023219
    (This article belongs to this Special Issue: Therapeutic Efficiency of Phyto-Molecules)
    Abstract As a traditional herbal medicine, the major alkaloids in Uncaria rhynchophylla have been proven to have blood pressure-lowering and sedative effects. It is essential to develop an effective method for the determination of the major alkaloids in U. rhynchophylla. In this research, a rapid quantitative analysis involving multi-components analysis by a single marker strategy coupled with core-shell column HPLC was adopted to analyse four alkaloids (corynoxeine, isocorynoxeine, isorhynchophylline, rhynchophylline) in U. rhynchophylla. Isorhynchophylline was selected as the internal reference substance, the content of which was determined by the traditional external standard method. Relative correction factors (RCF) between isorhynchophylline and the… More >

  • Open Access


    Phytochemical Analysis, Estimation of Quercetin, and in Vitro Anti-Diabetic Potential of Stevia Leaves Samples Procured from Two Geographical Origins

    Kuntal Das, Syed Mohammed Basheeruddin Asdaq, M. Saifulla Khan, Sravani Singirikonda, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Sreeharsha Nagaraja, Katharigatta N. Venugopala
    Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2349-2365, 2022, DOI:10.32604/phyton.2022.022379
    (This article belongs to this Special Issue: Therapeutic Efficiency of Phyto-Molecules)
    Abstract The current study used RP-HPLC to compare phytochemicals and estimate the bioactive constituents found in Stevia rebaudiana Bert. (SRB) leaves collected from two different geographical sources. SRB leaves were collected from Bangalore, Karnataka, India, and Reduit, Mauritius. Extracts were prepared using ethanol and aqueous solvents. Proximate analysis was used to evaluate moisture content, ash values, crude fibers, and extractive values. Following that, preliminary phytochemical screening was done on both ethanol leaves extracts, and subsequently total flavonoid content was determined. In addition, TLC chromatograms and RP-HPLC studies were performed on both plant extracts to determine the presence of flavonoid components in… More >

  • Open Access


    Assessment of Phytochemical Analysis, Nutritional Composition and Antimicrobial Activity of Moringa oleifera

    Naima Asghar, Abida Aziz, Muhammad Farooq Azhar , Mohamed El-Sharnouby, Uzma Irfan, Iqra Rafiq, Husnain Farooq, Muhammad Ishaq Asif Rehmani, Mohamed I. Sakran, A. Altalhi, Fahad M. Alzuaibr, Ayman El Sabagh
    Phyton-International Journal of Experimental Botany, Vol.91, No.8, pp. 1817-1829, 2022, DOI:10.32604/phyton.2022.020790
    (This article belongs to this Special Issue: Therapeutic Efficiency of Phyto-Molecules)
    Abstract Moringa oleifera is a miracle plant rich in nutrients, antioxidants, and antibiotic properties. Present study was designed to evaluate various biochemical attributes of leaves and flowers of M. oleifera. Plant parts (leaves, flowers) of M. oleifera, collected from different roadsides of Multan district, Punjab, Pakistan, were used as experimental material. Result indicates that alkaloids, saponin, carbohydrates, fats, and protein had a high value in the aqueous extract of both leaves and flowers of M. oleifera. Whereas phenol content was high in methanolic leaves extract and the phenol contents were high in aqueous extract of flowers. The extract yield of M.… More >

  • Open Access


    An Investigation of Molecular Targeting of MMP-9 for Endometriosis Using Algal Bioactive Molecules

    Farnaz Nabiya, Anchana Devi Chenniappan, Rajamiriyam Marichamy, MubarakAli Davoodbasha, Jung-Wan Kim
    Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 569-582, 2022, DOI:10.32604/phyton.2022.017390
    (This article belongs to this Special Issue: Therapeutic Efficiency of Phyto-Molecules)
    Abstract Endometriosis is a chronic inflammatory disease that occurs due to the presence of endometrial tissue outside the uterine cavity. It affects from 5% to 10% of women of reproductive age. High levels of matrix metalloproteinase (especially MMP-9) have been observed in women suffering from endometriosis. Thus, the aim of this study was to investigate the naturally anti-inflammatory compounds available from an algal source that can target the MMP-9 by various in silico approaches. The target 1L6J (Crystal structure of human matrix metalloproteinase MMP-9) structure was retrieved from the PDB database. Five compounds such as Eckol, Sargafuran, Vitamin E, Docosahexaenoic acid,… More >

  • Open Access


    Potential Antidiabetic and Anti-Genotoxic Activities of Silver Nanoparticles of Alkaloid Extract of Rhazya stricta in Rat Animal Model

    Mohammed Ali Ashehri
    Phyton-International Journal of Experimental Botany, Vol.90, No.6, pp. 1749-1762, 2021, DOI:10.32604/phyton.2021.016290
    (This article belongs to this Special Issue: Therapeutic Efficiency of Phyto-Molecules)
    Abstract In most of Arabian courtiers Rhazya stricta is extensively utilized in public medicine for several diseases treatment. In this study, crude alkaloid extract of R. stricta (CAERS) coated with silver nanoparticles (CAERS-AgNPs) as potential treatment against diabetes in DM animal model was evaluated. Swiss albino male rats (n = 80) were injected with STZ to induce Diabetes Mellitus type-2 (DM). DM-rats were injected different doses of CAERS or CAERS-nanoparticles (CAERS-NPs) for 2 months. The results exhibited that mRNA expression of insulin and insulin receptor was down-regulated, activity levels of antioxidant enzymes were decreased, generation of ROS mediated DNA adducts and apoptosis in… More >

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