Guest Editors
Prof. Hung-Yu Lin
Email: linhungyu700218@gmail.com
Affiliation: Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan
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Research Interests: cancer biology, biomarker, metabolism, mitochondria, immuno-oncology, non-coding RNAs, single-cell omics, targeted therapy, machine learning, cytokines
Summary
Cytokines are central regulators of the Tumor Microenvironment (TME), orchestrating complex cellular responses that extend beyond classical apoptosis and influencing tumor growth, immune surveillance, and tissue remodeling. This Special Issue focuses on how cytokine signaling networks modulate the spectrum of Regulatory Cell Death (RCD), including ferroptosis, pyroptosis, and necroptosis, and their dynamic crosstalk with autophagy, thereby shaping both tumor progression and immune microenvironment. We particularly encourage studies that elucidate molecular mechanisms by which cytokines regulate immune cell function, metabolic reprogramming, and inflammatory signaling within tumors, integrating mechanistic insights with disease-relevant models. This includes investigations of cytokine interactions with innate and adaptive immunity, their impact on tumor heterogeneity, and potential implications for therapeutic intervention. Original research and comprehensive reviews addressing these aspects, including translational perspectives such as biomarker development and cytokine-targeted strategies, are welcome.
Keywords
cytokines, tumor microenvironment, regulatory cell death, apoptosis,ferroptosis, pyroptosis, necroptosis, mitoxyperilysis, autophagy, inflammation, tumor progression, immune regulation, metabolic reprogramming, cytokine signaling, immuno-oncology, diagnosis, prognosis, therapy, precision medicine
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