Integrative Multi-Omics and Cytokine Networks in Inflammation-Driven Diseases: From Molecular Signatures to Translational Biomarkers

Submission Deadline: 31 March 2027 View: 49 Submit to Special Issue

Guest Editors

Prof. Chunguang Guo

Email: guochunguang0405@163.com

Affiliation: State Key Laboratory of Cardiovascular Disease, Center of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical Colege, Beijing, China

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Research Interests: cytokines; inflammation, single-cell sequencing, multi-omics, precision medicine, artificial intelligence

Dr. Zaoqu Liu

Email: liuzaoqu@163.com

Affiliation: Institute of Basic Medical Sciences, Peking Union Medical College (PUMC), Beijing, China

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Research Interests: cytokines, inflammation, multi-omics, single-cell RNA sequencing

Dr. Jialin Meng

Email: mengjialin@ahmu.edu.cn

Affiliation: University of Science and Technology of China, Hefei, China

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Research Interests: immune microenvironment, biomarkers, systems biology

Summary

Chronic inflammation is a fundamental driver of a wide spectrum of diseases, including cardiovascular disorders, metabolic syndromes, autoimmune conditions, and cancer. Cytokines and their associated signaling networks play central roles in orchestrating immune responses, mediating intercellular communication, and shaping disease progression. Despite substantial advances in understanding individual cytokines, the complexity and heterogeneity of cytokine interactions in human diseases remain incompletely characterized.

Recent developments in multi-omics technologies-including transcriptomics, single-cell RNA sequencing, proteomics, and spatial omics-have provided unprecedented opportunities to systematically dissect cytokine-driven regulatory networks at high resolution. These approaches enable the identification of cell-type-specific inflammatory signatures, intercellular communication pathways, and novel biomarkers for early diagnosis, risk stratification, and therapeutic targeting.

This Special Issue aims to bridge the gap between traditional cytokine biology and emerging multi-omics strategies, with a particular focus on inflammation-related diseases. We welcome studies that integrate multi-dimensional data to elucidate cytokine networks, characterize immune cell heterogeneity, and translate molecular findings into clinically actionable biomarkers.

Suggested topics include, but are not limited to:
1. Multi-omics profiling of cytokine networks in human diseases
2. Single-cell and spatial transcriptomics of inflammatory microenvironments
3. Cytokine-mediated intercellular communication and signaling pathways
4. Identification of inflammation-related diagnostic and prognostic biomarkers
5. Systems biology and network analysis of immune responses
6. Integration of proteomics and transcriptomics in cytokine research
7. Cytokines in cardiovascular and metabolic diseases
8. Translational studies linking cytokine signatures to clinical outcomes
9. Novel therapeutic targets within cytokine signaling pathways

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