Guest Editors
Prof. Dr. Denise Mafra
Email: dm@id.uff.br
Affiliation: 1. Graduate Program in Biological Sciences – Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
2. Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Rio de Janeiro, Brazil
Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Rio de Janeiro, Brazil
Homepage:
Research Interests: renal nutrition
Dr. Jessyca Sousa de Brito
Email: jessyca@biof.ufrj.br
Affiliation: Graduate Program in Biological Sciences – Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
Homepage:
Research Interests: renal nutrition
Summary
Chronic diseases such as cardiovascular disease, diabetes, chronic kidney disease, obesity, neurodegenerative disorders, and autoimmune conditions are frequently characterized by persistent low-grade inflammation. Dysregulation of cytokine production and signaling pathways plays a central role in the initiation and progression of these disorders, influencing immune responses, oxidative stress, metabolic imbalance, and tissue damage.
Understanding the molecular and cellular mechanisms underlying cytokine-mediated inflammation is essential for identifying novel therapeutic targets and improving disease management strategies. Advances in molecular biology, immunology, metabolomics, and systems biology have provided new insights into inflammatory pathways and their role in chronic disease pathophysiology.
This Special Issue aims to gather original research articles and comprehensive reviews addressing the role of inflammation and cytokine biology in chronic diseases. We welcome studies exploring mechanistic pathways, clinical implications, and potential therapeutic strategies targeting inflammatory and cytokine-mediated processes.
Topics of interest include, but are not limited to:
· Cytokine signaling pathways and inflammatory mechanisms in chronic diseases
· Role of inflammation in cardiometabolic, renal, and neurodegenerative disorders
· Interactions between oxidative stress, immune response, and cytokine production
· Biomarkers of inflammation and cytokine profiles in chronic disease progression
· Nutritional, pharmacological, or lifestyle interventions targeting inflammatory pathways
· Emerging therapeutic targets in cytokine-mediated diseases
· Translational and clinical studies focusing on inflammatory modulation
· Both original research articles and narrative or systematic reviews are encouraged.
Keywords
inflammation, cytokines, chronic diseases, immune dysregulation, oxidative stress, inflammatory signaling pathways, therapeutic targets
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