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Unraveling the Molecular and Cellular Mechanisms of Amyotrophic Lateral Sclerosis (ALS)

Submission Deadline: 01 April 2025 Submit to Special Issue

Guest Editors

Prof. Weijiang Zhao, Department of Cell Biology, Wuxi School of Medicine, Jiangnan University, China. weijiangzhao@jiangnan.edu.cn
Dr. Milena Jankovic, Neurology Clinic, University Clinical Center of Serbia, Serbia. milena.jankovic.82@gmail.com


Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons, leading to muscle weakness and paralysis. While ALS was traditionally viewed as a motor neuron-centric disorder, recent advances have highlighted its multifaceted nature, involving complex interactions between neurons and non-neuronal cells.


This Special Issue aims to explore the latest research on the molecular and cellular mechanisms underlying ALS, with a focus on understanding disease pathogenesis and identifying novel therapeutic targets. It welcomes original research articles, reviews, and perspectives that address various aspects of ALS, including but not limited to:

1. Molecular pathways implicated in ALS pathogenesis, such as mitochondrial dysfunction, oxidative stress, protein misfolding and aggregation, and RNA metabolism.

2. Cellular mechanisms contributing to motor neuron degeneration, including axonal transport defects, glial cell dysfunction, and neuroinflammation.

3. Genetic and epigenetic factors influencing ALS risk and disease progression.

4. Emerging technologies and model systems for studying ALS, including induced pluripotent stem cells (iPSCs), organoids, and novel animal models.

5. Translational research efforts aimed at developing novel therapeutics and biomarkers for ALS diagnosis and treatment.


Authors are invited to submit original research articles, reviews, or perspectives to this Special Issue through the journal's online submission system. By bringing together diverse perspectives and cutting-edge research, this collection will provide a comprehensive overview of the current state of ALS research, highlighting key advances in our understanding of the molecular and cellular mechanisms driving disease pathogenesis.


amyotrophic lateral sclerosis, motor neuron degeneration, molecular pathways, neurodegenerative disease, RNA metabolism, glial cell dysfunction, biomarkers

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