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Genetic and environmental factors in cartilage and bone diseases

Submission Deadline: 31 December 2023 (closed)

Guest Editors

Dr. Sen Wang, School of Public Health, Health Science Center, Xi’an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission, Xi’an, Shaanxi, China
E-mail: senwang2016@163.com

Dr. Dimiao Wang, School of Nursing, Health Science Center, Xi’an Jiaotong University, Xi'an, Shaanxi, China
E-mail: wangdm-5821@163.com


Cartilage and bone diseases are a large group of complex diseases that result from the interaction of genes and environmental factors. The range of environmental factors is wide, such as age, gender, occupation, health condition, daily diet and habits, trace elements in food, air, water and soil. Meanwhile, genes play essential roles in the pathogenesis of cartilage and bone diseases. Cartilage and bone diseases have a serious impact on a person's quality of life and work. The use of traditional medicine to analyze the etiology and pathogenesis of cartilage and bone diseases is no longer sufficient to meet the needs of scientific research and clinical practice. It has gradually become a trend to analyze the etiology and pathogenesis of the cartilage and bone diseases from the perspective of the interaction of genes and environment.


In recent years, the roles of genetic and environmental factors in cartilage and bone diseases were investigated with the rapid development. High-throughput sequencing technology, genome, pharmacogenomics, proteome, metabolome, transcriptome, and single-cell sequencing were used to explore the pathogenesis and therapeutic targets of cartilage and bone diseases, delaying the progression of cartilage and bone diseases, and new diagnostic and treatment methods have always been the focus of cartilage and bone diseases. The primary goal of this topic is to provide cutting-edge research in the roles of genetic and environmental factors in cartilage and bone diseases, including genomics, proteomics, metabolomics, transcriptomics, multi-omics data, GWAS analysis, biomarkers, molecular mechanism, and the discovery of new gene associations.

This research topic welcomes the submission of bioinformatics analysis, cell and animal experiments, and reviews focused on, but not limited to, the following topics:
(1) Multi-omics data analysis (genomics, proteomics, metabolomics, and transcriptomics) of bone and joint diseases.
(2) Novel biomarkers in the pathogenesis of degenerative cartilage and bone disease.
(3) New genes diagnostic model of cartilage and bone diseases.
(4) Cell and animal models of cartilage and bone diseases.
(5) Genetic and environmental factors-related cartilage and bone diseases.


orthopedics, articular disease, chondrocyte, Kaschin-Beck disease, gene, environment

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