Special Issues
Table of Content

Medicinal Plants: Phytochemical and Pharmacological Research

Submission Deadline: 30 November 2026 View: 1367 Submit to Special Issue

Guest Editor(s)

Prof. Dr. Oleh Koshovyi

Email: oleh.koshovyi@ut.ee

Affiliation: Institute of Pharmacy, University of Tartu, Estonia

Homepage:

Research Interests: pharmacy, pharmacognosy, pharmacognosy, medicinal plants, phytochemistry, nanomedicine

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Prof. Dr. Ain Raal

Email: ain.raal@ut.ee

Affiliation: Institute of Pharmacy, University of Tartu, Estonia

Homepage:

Research Interests: pharmacy, pharmacognosy, phytochemistry, phytotherapy, ethnomedicine, ethnobotany, history of pharmacognosy

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Summary

Medicinal plants have played a central role in healthcare systems across civilizations for centuries, serving as valuable sources for the prevention and treatment of a wide range of diseases. Empirical knowledge on the therapeutic use of plant raw materials and plant-derived preparations has been accumulated over long historical periods; however, much of this knowledge still requires rigorous scientific validation. Although a vast amount of information on medicinal plants is currently available, the efficacy, safety, and mechanisms of action of many plant-based remedies remain insufficiently substantiated by modern scientific approaches.


In this context, we invite researchers to contribute original scientific studies focusing on phytochemical and pharmacological investigations of medicinal plants. This Special Issue of Phyton aims to present recent advances in the characterization of chemical constituents, their qualitative and quantitative composition, evaluation of biological and pharmacological activities, and the development, standardization, and quality control of herbal supplements and medicines. We welcome high-quality manuscripts addressing the isolation, identification, and qualitative or quantitative analysis of plant-derived compounds, as well as in vitro and in vivo studies elucidating their pharmacological potential.


In addition, research related to medicinal plant cultivation, authentication of plant materials, standardization strategies, and the design of dosage forms based on plant-origin substances falls within the scope of this Special Issue. Submissions limited exclusively to phytochemical profiling without biological evaluation, or only qualitative analyze, or pharmacological studies lacking phytochemical characterization, will not be considered.


Keywords

medicinal plants, plant raw materials, extracts, natural compounds, phytochemicals, phytochemical analysis, isolation, identification, pharmacological activity, dosage forms, standardization, quality assurance

Published Papers


  • Open Access

    ARTICLE

    Phytochemical Profiling and Biological Activity Screening of Anemone nemorosa L. Extracts with Anti-Inflammatory and Hepatoprotective Effects

    Liliia Tuzin, Andriy Grytsyk, Ain Raal, Roman Hrytsyk, Valdas Jakštas, Vaidotas Žvikas, Nataliia Dubel, Oleh Koshovyi
    Phyton-International Journal of Experimental Botany, DOI:10.32604/phyton.2026.089037
    (This article belongs to the Special Issue: Medicinal Plants: Phytochemical and Pharmacological Research)
    Abstract This study represents a preliminary phytochemical and pharmacological screening of Anemone nemorosa L. collected in Ukraine. The aim was to characterize the phytochemical composition of the herb, rhizomes, and extracts obtained using solvents of different polarity, and to perform an initial evaluation of their toxicity, anti-inflammatory, hemostatic, and hepatoprotective activities. UPLC–MS/MS analysis identified 12 phenolic compounds, including flavonoids and hydroxycinnamic acids, with the highest level observed in AN-40 extract (obtained using 40% ethanol). Their content varies depending on the plant organ, location, and year of collection. For the first time, amino acid profiling identified 14 amino… More >

  • Open Access

    ARTICLE

    Phytochemical Profiling and Pharmacological Evaluation of Astrantia major L. Herb Extracts with Systemic Anti-Inflammatory and Topical Hemostatic, Wound-Healing, and Antimicrobial Activities

    Taras Koliadzhyn, Andriy Grytsyk, Nadiia Lehin, Lubov Grytsyk, Ain Raal, Oleh Koshovyi
    Phyton-International Journal of Experimental Botany, DOI:10.32604/phyton.2026.085064
    (This article belongs to the Special Issue: Medicinal Plants: Phytochemical and Pharmacological Research)
    Abstract Astrantia major L. (Apiaceae) is a non-official medicinal plant with a long history of use in the traditional medicine of many European countries; however, its phytochemical composition and pharmacological properties remain insufficiently studied. This study aimed to investigate the phenolic profile of A. major herb extracts and evaluate their biological activities. A total of 17 phenolic compounds were identified, including hydroxycinnamic acids, flavonoids, catechins and tannin-related metabolites. Chlorogenic acid was the predominant hydroxycinnamic acid, while rutin was the major flavonoid. Among the tannin-related metabolites, gallocathechin predominated in the aqueous extract (AM0), whereas epigallocatechin was the major constituent… More >

  • Open Access

    ARTICLE

    Exploring the Therapeutic Potential of Horwoodia dicksoniae through Phytochemical Profiling, Antioxidant Assessment, and Biological Activity Evaluation

    Aiman Ammari, Ramzi Amran, Ahmad Alhimaidi
    Phyton-International Journal of Experimental Botany, Vol.95, No.8, 2026, DOI:10.32604/phyton.2026.087258
    (This article belongs to the Special Issue: Medicinal Plants: Phytochemical and Pharmacological Research)
    Abstract Medicinal plants are valuable sources of bioactive compounds with diverse pharmacological properties. However, the phytochemical composition and biological activities of Horwoodia dicksoniae remain insufficiently investigated. Therefore, this study evaluated the phytochemical composition, antioxidant activity, physicochemical characteristics, and in vitro cytotoxic potential of the ethanolic extract of H. dicksoniae collected from the Thumamah area, Riyadh, Saudi Arabia. The extract was subjected to phytochemical characterization, chemical profiling, physicochemical analysis, antioxidant activity assessment, and cytotoxicity evaluation. Qualitative screening confirmed the presence of phenolics, flavonoids, tannins, terpenoids, and glycosides, while quantitative analysis revealed high levels of phenolic and tannin constituents. The extract… More >

    Graphic Abstract

    Exploring the Therapeutic Potential of <i>Horwoodia dicksoniae</i> through Phytochemical Profiling, Antioxidant Assessment, and Biological Activity Evaluation

  • Open Access

    ARTICLE

    Co-Analysis of Metabolomics and Transcriptomics Reveals Key Pathways and Genes Associated with Pigment and Flavonoid Regulation in Mint

    Xiangdong Wang, Hailong An, Yanzhi Ma, Hong Chen, Qi Sun, Shaoying Ke
    Phyton-International Journal of Experimental Botany, Vol.95, No.8, 2026, DOI:10.32604/phyton.2026.083016
    (This article belongs to the Special Issue: Medicinal Plants: Phytochemical and Pharmacological Research)
    Abstract Mint is notably rich in phenolic acids, flavonoids, antioxidants and other bioactive components, and is widely used as food, medicine, spices, and flavoring agents. Thus, metabolite composition serves as a critical indicator for assessing mint quality. In this study, two mint genotypes of Mentha canadensis L., were sampled, namely purple mint and green mint. The two genotypes are distinguished by stem color: the purple mint exhibits purple stems, whereas the green mint has green stems. The purple mint exhibited significantly higher anthocyanin and total flavone contents than green mint. Integrated transcriptomic and metabolomic analyses were performed… More >

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