Guest Editors
Dr. Bulat R. Kuluev
Email: kuluev@bk.ru
Affiliation: Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia
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Research Interests: molecular biology, genetic engineering, genome editing
Dr. Elena Mikhaylova
Email: mikhele@list.ru
Affiliation: Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia
Homepage:
Research Interests: CRISPR/Cas, molecular biology, viral vectors, transgene-free genome editing
Summary
Plants are negatively affected by many stress factors, mainly hypothermia, drought, salinity, heat, and heavy metals. Due to their sessile lifestyle, plants must adapt to these unfavorable abiotic environmental conditions. In response to stress, many regulatory systems are activated in plants. In general, a plant's resistance to a particular stress factor is determined by the expression of many genes encoding protective proteins. To date, a significant number of transgenic plants with increased resistance to abiotic stress have been created. However, the real revolution was the development of the CRISPR/Cas genome editing method, where the site of action of the editing nuclease is determined by a short sgRNA. In this case, editing can be done by knocking out a gene or inserting a target gene into the edited region (knock-in). This is a very intensively developing and promising area of plant science, which is of great importance both for fundamental science and for plant growing and crop production. For this research topic, we welcome reviews, perspectives, original research, opinions, and methods that highlight the latest exciting progress in genome editing, in the creation of new plant forms, in the functioning of genes and gene networks, and in the molecular mechanisms of resistance to abiotic stress. Potential subjects for this topic include, but are not limited to:
· Development of new approaches for genome editing of plants to increase their stress resistance.
· Experimental work on knockout and knock-in editing of genes involved in the regulation of stress resistance.
· Creating edited plants with increased resistance to abiotic stress.
· Studying the molecular mechanisms of stress resistance by analyzing edited plants.
· Creation of new varieties of cultivated plants using genome editing methods.
· Methods for analyzing edited plants.
· Legislation on the admission of edited plants for industrial cultivation.
Keywords
abiotic stress, drought, salinity, hypothermia, heat, heavy metals, CRISPR/Cas, genome editing, genetic engineering, edited plants.
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