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Regulation of Immune Cell Functions in Tumor Microenvironment

Submission Deadline: 01 July 2024 Submit to Special Issue

Guest Editors

Peng Xiao, Zhejiang University, China, tulipxp@zju.edu.cn
Yinjing Song, Zhejiang University, China, 11218067@zju.edu.cn
Lu Sun, University of Michigan (Current), USA, lusun@umich.edu


The immunosuppressive microenvironment present in tumor tissues presents significant challenges to effective anti-tumor immunity and cancer immunotherapy. Dysfunctions in immune cells, including macrophages, T cells, neutrophils, and dendritic cells, play a major role in facilitating tumor immune evasion. Addressing the reversal of the immunosuppressive properties exhibited by tumor-infiltrating immune cells has remained a top priority in cancer treatment. Furthermore, the identification of key molecules that regulate immune cell functions within the tumor microenvironment, along with a comprehensive understanding of their mechanisms of action, may offer new targets for cancer immunotherapy.


The objective of this special issue is to advance our current understanding of the regulatory mechanisms governing immune cell functions in cancer. We invite original research articles and reviews that explore the following areas:

(1) Discovery of novel immune cell populations or molecules that influence anti-tumor immunity.

(2) Elucidation of the molecular mechanisms underlying the regulatory roles of immune cells in cancer progression.

(3) Targeting immune cells in cancer immunotherapy.

(4) Identification of new biomarkers associated with immune cells that can predict patients' response to immunotherapy.


Please note that we do not accept studies solely comprising bioinformatics analysis of public databases without any validation data.


cancer, immune cells, cancer immunotherapy, tumor microenvironment

Published Papers

  • Open Access


    FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma

    BIOCELL, Vol.47, No.11, pp. 2503-2516, 2023, DOI:10.32604/biocell.2023.031565
    (This article belongs to the Special Issue: Regulation of Immune Cell Functions in Tumor Microenvironment)
    Abstract Background: Non-small cell lung cancer (NSCLC) has a poor prognosis with a low 5-year survival rate. Lung adenocarcinoma (LUAD) accounts for 50%. Facio-genital dysplasia-5 (FGD5), a member of a subfamily of Rho GTP-GDP exchange factors, may be a good molecular biomarker for diagnosis and prognosis. Objective: To explore the clinical application of FGD5, the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients. Methods: Through the Wilcoxon signed-rank test and logistic regression, the correlation between clinical characteristics and FGD5 expression was analyzed. Kaplan–Meier plotter analysis,… More >

    Graphic Abstract

    FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma

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