Guest Editors
Prof. Julia Fedotova，ITMO University, Russia
Prof. Lucian Hritcu, Universitatea Alexandru Ioan Cuza, Roumania
Prof. Peter Kruzliak, Comenius University, Slovakia
Prof. Vittorio Unfer, nstitut des Etudes Universitaires, Switzerland
Summary
Today's approaches to dissect the neurobiology of depression employ an
unprecedented array of experimental techniques in humans and animals,
including genome-wide DNA sequencing, chromatin immunoprecipitation to
study epigenetic factors, functional brain imaging, optogenetic
electrophysiological tools, viral-mediated gene transfer and an
impressive assortment of genetic mutant mice. The list of molecular
players involved in depression's phenotypes has now expanded to include
genes from diverse aspects of cellular physiology such as numerous
neurotransmitter and neuropeptide systems, steroid hormones,
neurotrophic and cytokine signaling cascades, ion channels, circadian
genes, phytochemicals, and many others. Most of the new targets are
derived from experiments in rodents and, while these studies are
scientifically sound, the targets themselves may or may not be
therapeutically relevant or feasible for human depression.
This special issue in the journal BIOCELL is intended to new molecules
and new approaches for treatment of depression in preclinical and
clinical studies.
Keywords
Neurobiology, Depression, Treatment of Mood Disorders, Novel Molecules, Novel Approaches
Published Papers
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Open Access
ARTICLE
Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis
XIAOYU WANG, TAKESHI YAMAMOTO, MAKOTO KADOWAKI, YIFU YANG
BIOCELL, Vol.45, No.2, pp. 395-415, 2021, DOI:10.32604/biocell.2021.012280
（This article belongs to this Special Issue:
New Insights in Biology of Depression: New Molecules and Approaches)
Abstract Mast cells are the main effector cells in IgE-associated allergic disorders, and we have reported that mucosal
mast cells (MMCs) play a more important role in the development of food allergy (FA). IgE with antigen or calcium
ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway. The purpose of the
present study was to identify gene signatures with IgE/antigen (dinitrophenyl-bovine serum albumin, DNP-BSA) or
calcium ionophore (A23187) on the activation of MMCs. Differentially expressed genes between the two types of
samples were identified with microarray analysis. Gene ontology functional and pathway enrichment analyses of
differentially expressed…
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Open Access
ARTICLE
Nanoparticles induce the biosynthesis and activity of the new possible therapeutic proteinase source, Talaromyces purpureogenus KJ584844
SALLY NEGM, MOHAMMAD EL-METWALLY, WESAM ELDIN SABER, SAHAR ABO-NEIMA, MAHMOUD MOUSTAFA, ATTALLA EL-KOTT
BIOCELL, Vol.45, No.1, pp. 119-127, 2021, DOI:10.32604/biocell.2021.012011
（This article belongs to this Special Issue:
New Insights in Biology of Depression: New Molecules and Approaches)
Abstract The need for the bacterial proteinase is rapidly growing, urging to catch a lowcost medium for the microbial
fermentation, nanoparticles can play a vital role in this respect. The proteinase of
Talaromyces purpureogenus was
produced on the tubers of
Helianthus tuberosus that also operated as solid support for the fermentation process. The
interface amongst nitrogen sources (NH
4Cl and yeast extract) was investigated, applying the statistical modeling of
central composite design under solid-state fermentation. The optimum medium for proteinase secretion was
stimulated by 979.82 mg NH
4Cl and 437.68 mg yeast extract per 100 g substrate, yielding 108.15 U/g tubers. Using
Plackett-Burman…
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Open Access
ARTICLE
Expression profiling of immune cells in systemic lupus erythematosus by single-cell RNA sequencing
XIANLIANG HOU, DONGE TANG, FENGPING ZHENG, MINGLIN OU, YONG XU, HUIXUAN XU, XIAOPING HONG, XINZHOU ZHANG, WEIER DAI, DONGZHOU LIU, YONG DAI
BIOCELL, Vol.44, No.4, pp. 559-582, 2020, DOI:10.32604/biocell.2020.011022
（This article belongs to this Special Issue:
New Insights in Biology of Depression: New Molecules and Approaches)
Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abnormal cellular and
humoral immune responses and excessive autoantibody production. The precise pathologic mechanism of SLE remains
elusive. The advent of single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the molecular differences of
cell populations at the single-cell level. We used scRNA-seq to profile the transcriptomes of peripheral blood
mononuclear cells from an SLE patient compared with a healthy control (HC). A total of 16,021 cells were analyzed
and partitioned into 12 distinct clusters. The marker genes of each cluster and the four major immune cell types
(B cells,…
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