Guest Editors
Prof. Dr. Chung-Yi Chen
Email: xx377@fy.edu.tw
Affiliation: School of Medical and Health Sciences, Fooyin University, Kaohsiung City, 83102, Taiwan
Homepage:
Research Interests: phytochemical, natural product, medicinal chemistry
Dr. Chi-Ming Liu
Email: beagleliu@gmail.com
Affiliation: School of Medicine, Yichun University, Yuanzhou District, 576 XueFu Road, 336000, Yichun, P. R. China
Homepage:
Research Interests: EMT, BPH, prostate cancer, phytochemicals
Summary
Epithelial-Mesenchymal Transition (EMT) is a vital cellular process that plays a significant role in various physiological functions and disease pathologies. EMT contributes to the development and progression of benign prostatic hyperplasia (BPH) as well as cancer metastasis. Transforming growth factor-beta (TGF-β) is a well-known and potent inducer of EMT. Additionally, androgens interact with TGF-β signaling pathways to cooperatively promote EMT, thereby facilitating the pathological progression of BPH and prostate cancer metastasis. Given its central role, reversing EMT has emerged as a promising therapeutic strategy to combat these diseases.
Aim and Scope of the Special Issue
Although considerable research has been dedicated to EMT, gaps remain in our understanding of the novel regulatory mechanisms involved. This Special Issue aims to provide a platform for studies focusing on newly discovered signaling pathways and cytokines that regulate EMT in the context of BPH and prostate cancer metastasis. Moreover, we encourage submissions exploring innovative medications or compounds that can effectively reverse EMT, thereby offering potential therapeutic benefits. Both experimental and clinical research contributions, as well as comprehensive reviews, are welcomed.
Suggested Themes
- The role of pro-inflammatory cytokines and chemokines in inducing EMT during BPH development.
- Interactions between androgens and pro-inflammatory cytokines in regulating EMT.
- Novel signaling pathways involved in EMT regulation.
- Phytochemicals and synthetic compounds with potential to reverse EMT.
This issue invites original research, reviews, and clinical studies that contribute to a deeper understanding and better integration of andrology in reproductive health care.
Keywords
EMT, prostate cancer, cytokine, BPH, TGF-β, chemokines, inflammation, phytochemicals
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