Table of Content

Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors

Submission Deadline: 31 July 2022 (closed)

Guest Editors

Professor Marco Tatullo, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Italy.


Tissue engineering and Regenerative Medicine (TERM) are deeply changing several medical procedures and are offering opportunities to regenerate human tissues and organs previously considered utopistic. Stem cells and Biomaterials are the main actors of tissue regeneration: the proper combination of these factors, and their interaction with local and systemic bioactive molecules, are the key to successfully approach the treatment of damaged or lost tissues. Stem Cells have been discovered in almost all the human tissues and organs, creating increasing interest towards the characterization of stem cell subsets and their behavior. Biomaterials are also subjected to a wide rethinking of their functionality: smart materials, bioactive molecules and nanotechnologies could be the keywords that will impact the biomaterials science in the forthcoming years. The future approaches of translational medicine should overcome the current biological and clinical limitations and should be able to involve the TERM in each regenerative protocol.

This special issue aims to stimulate worldwide researchers, academicians and expert at sharing their most interesting and promising research. We strive to publish innovative results on several aspects of Regenerative Medicine, Biomaterials, Scaffolds, Stem cells, Smart materials, Exosomes, Functionalized surfaces, Coatings, Bioactive surfaces, and similar ones. We do encourage top-scientists to send us their commentaries, opinion papers, topical reviews, perspective articles and proposals to this special issue.


Regenerative Medicine, Biomaterials, Scaffolds, Stem Cells, Smart Materials, Exosomes, Functionalized Surfaces, Coatings, Bioactive Surfaces

Published Papers

  • Open Access


    The antioxidant trolox inhibits aging and enhances prostaglandin E-2 secretion in mesenchymal stem cells

    BIOCELL, Vol.47, No.2, pp. 385-392, 2023, DOI:10.32604/biocell.2023.025203
    (This article belongs to this Special Issue: Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors)
    Abstract Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. However, during in vitro expansion, MSCs are prone to aging, which largely limits their application. Prostaglandin E-2 (PGE-2) is a key effector secreted by MSCs to exert immunomodulatory effects. By screening the compound library for PGE-2 secretion, the antioxidant trolox was verified as a stimulator of MSCs to secrete PGE-2. The effect of antioxidant trolox on biological characteristics of MSCS, including aging, proliferation, and gene expression, was examined. The results demonstrated that trolox can resist aging,… More >

  • Open Access


    CRISPR accelerates the cancer drug discovery

    BIOCELL, Vol.46, No.10, pp. 2159-2165, 2022, DOI:10.32604/biocell.2022.021107
    (This article belongs to this Special Issue: Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors)
    Abstract Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients, such as gene mutation, amplification, or deletion, with the overall survival prognosis, underscoring patients’ genetic background may directly regulate drug sensitivity/resistance during chemotherapies. Understanding the molecular mechanism underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the cancer drug discovery. The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science research, providing a precise and simplified genome editing tool with unlimited editing possibilities. Furthermore, it presents a powerful tool in cancer drug discovery, which hopefully facilitates us with… More >

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