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Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors

Submission Deadline: 31 July 2022 (closed)

Guest Editors


Professor Marco Tatullo, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Italy. marco.tatullo@uniba.it

Summary

Tissue engineering and Regenerative Medicine (TERM) are deeply changing several medical procedures and are offering opportunities to regenerate human tissues and organs previously considered utopistic. Stem cells and Biomaterials are the main actors of tissue regeneration: the proper combination of these factors, and their interaction with local and systemic bioactive molecules, are the key to successfully approach the treatment of damaged or lost tissues. Stem Cells have been discovered in almost all the human tissues and organs, creating increasing interest towards the characterization of stem cell subsets and their behavior. Biomaterials are also subjected to a wide rethinking of their functionality: smart materials, bioactive molecules and nanotechnologies could be the keywords that will impact the biomaterials science in the forthcoming years. The future approaches of translational medicine should overcome the current biological and clinical limitations and should be able to involve the TERM in each regenerative protocol.



This special issue aims to stimulate worldwide researchers, academicians and expert at sharing their most interesting and promising research. We strive to publish innovative results on several aspects of Regenerative Medicine, Biomaterials, Scaffolds, Stem cells, Smart materials, Exosomes, Functionalized surfaces, Coatings, Bioactive surfaces, and similar ones. We do encourage top-scientists to send us their commentaries, opinion papers, topical reviews, perspective articles and proposals to this special issue.


Keywords

Regenerative Medicine, Biomaterials, Scaffolds, Stem Cells, Smart Materials, Exosomes, Functionalized Surfaces, Coatings, Bioactive Surfaces

Published Papers


  • Open Access

    ARTICLE

    Circulating tumor cells: Biological features and survival mechanisms

    XIAOFENG LI, JINYANG ZHENG, JINFENG ZHU, XIN HUANG, HUANHUAN ZHU, BINGDI CHEN
    BIOCELL, Vol.47, No.8, pp. 1771-1781, 2023, DOI:10.32604/biocell.2023.028343
    (This article belongs to this Special Issue: Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors)
    Abstract Circulating tumor cells (CTCs) are neoplastic cells that are detached from primary tumors and enter circulation. Enumeration and characterization of CTCs are of significance in cancer diagnosis, prognosis, and treatment monitoring. CTC survival in the bloodstream is a limiting step for the development of metastases in distant organs. Recent technological advances, especially in single-cell molecular analyses have uncovered heterogeneous CTC survival mechanisms. Undergoing epithelial-to-mesenchymal transition (EMT), increasing stem cell-like properties, and forming cell clusters enable CTCs to adapt to the harsh microenvironment of the circulation. Expressing and releasing several immunosuppressive molecules help CTCs escape from anti-cancer immune mechanisms. This review… More >

  • Open Access

    ARTICLE

    Comparative studies on the binding site of anesthetics to GABA a receptors using in silico docking methods

    SEUNGHYUN AHN, JUNG-YEON LEE, JIHA SUNG, HYUN JOO KIM, SEYEON PARK
    BIOCELL, Vol.47, No.7, pp. 1661-1673, 2023, DOI:10.32604/biocell.2023.027984
    (This article belongs to this Special Issue: Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors)
    Abstract Background: Although the GABAA receptor (GABAAR) has been proposed as the main action site for sevoflurane, isoflurane, halothane, enflurane, propofol, and benzodiazepines (BZDs), binding of these anesthetics with high-resolution structures of the GABAAR have been rarely examined by comparative docking analyses. Moreover, various combinations of ligands on more GABAARs with various subtypes need to be analyzed to understand the elaborate action mechanism of GABAARs better because some GABAA ligands showed specificity toward the distinct subtypes of the GABAAR. Methods: We performed in silico docking analysis to compare the binding modes of sevoflurane, isoflurane, halothane, enflurane, propofol, and BZDs to the… More >

  • Open Access

    ARTICLE

    The antioxidant trolox inhibits aging and enhances prostaglandin E-2 secretion in mesenchymal stem cells

    XIAOXU ZHANG, LIN ZHANG, LIN DU, HUIYAN SUN, XIA ZHAO, YANG SUN, WEI WANG, LISHENG WANG
    BIOCELL, Vol.47, No.2, pp. 385-392, 2023, DOI:10.32604/biocell.2023.025203
    (This article belongs to this Special Issue: Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors)
    Abstract Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. However, during in vitro expansion, MSCs are prone to aging, which largely limits their application. Prostaglandin E-2 (PGE-2) is a key effector secreted by MSCs to exert immunomodulatory effects. By screening the compound library for PGE-2 secretion, the antioxidant trolox was verified as a stimulator of MSCs to secrete PGE-2. The effect of antioxidant trolox on biological characteristics of MSCS, including aging, proliferation, and gene expression, was examined. The results demonstrated that trolox can resist aging,… More >

  • Open Access

    ARTICLE

    CRISPR accelerates the cancer drug discovery

    RUYU YAN, JUNJIE WANG, MINXIA LIU, KECHENG ZHOU
    BIOCELL, Vol.46, No.10, pp. 2159-2165, 2022, DOI:10.32604/biocell.2022.021107
    (This article belongs to this Special Issue: Expert Opinions and Future Trends on Stem Cells, Biomaterials and Growth Factors)
    Abstract Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients, such as gene mutation, amplification, or deletion, with the overall survival prognosis, underscoring patients’ genetic background may directly regulate drug sensitivity/resistance during chemotherapies. Understanding the molecular mechanism underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the cancer drug discovery. The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science research, providing a precise and simplified genome editing tool with unlimited editing possibilities. Furthermore, it presents a powerful tool in cancer drug discovery, which hopefully facilitates us with… More >

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