Special Issues
Table of Content

Advances and Challenges In Male Infertility: From Molecular Mechanisms to Clinical Applications

Submission Deadline: 30 June 2026 View: 288 Submit to Special Issue

Guest Editors

Dr. Debbie Montjean

Email: debbie.montjean@fertilys.org

Affiliation: Fertilys Centers, 1950 Maurice-Gauvin Street, Laval, QC H7S 1Z5, Canada

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Research Interests: Reproductive and developmental biology,physiology and pathophysiology of reproduction, genetic and epigenetic anomalies in male infertility, clinical and research embryology, IVF laboratory management and assisted reproductive technologies


Dr. Soukaina Azil

Email: sazil@um6ss.ma

Affiliation: Immunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Université Mohammed VI des Sciences de la Santé, Casablanca, Morocco

Homepage:

Research Interests: Male infertility,andrology,sperm physiology,oxidative stress, cytokines in seminal plasma,  sperm DNA fragmentation, assisted reproductive technologies (ART),  oocyte activation mechanisms


Summary

Male infertility is a significant global health issue, accounting for nearly 50% of all infertility cases in couples. It is a complex and multifactorial condition, involving genetic, epigenetic, environmental, hormonal, and immunological components. Over the past decades, advances in reproductive medicine have greatly improved our understanding of spermatogenesis, sperm function, and the molecular mechanisms underlying male infertility. However, a large proportion of cases remain idiopathic, highlighting the urgent need for deeper investigations into novel biomarkers, diagnostic tools, and therapeutic strategies. This Special Issue aims to address these knowledge gaps and foster the dissemination of cutting-edge research in the field of male reproductive health.


Keywords

male infertility, sperm function, cytokines, oxidative stress, ART, DNA fragmentation, spermatogenesis, reproductive immunology

Published Papers


  • Open Access

    REVIEW

    A comprehensive review about sperm-oocyte interactions and key activation factors of fertilization in mammals

    Soukaina Azil, Yassmine Louanjli, Noureddine Louanjli, Moncef Benkhalifa, Bouchra Ghazi
    Canadian Journal of Urology, Vol.33, No.1, pp. 51-62, 2026, DOI:10.32604/cju.2025.069420
    (This article belongs to the Special Issue: Advances and Challenges In Male Infertility: From Molecular Mechanisms to Clinical Applications)
    Abstract Mammalian fertilization involves the migration of spermatozoa through the female reproductive system. Early embryonic development is a consequence of several steps and signaling pathways being activated, as well as biochemical and morphological modifications of spermatozoa that enable them to penetrate the membrane of mature oocytes.
    There are some crucial steps known to clearly explain the process of fertilization, starting with hyperactivation of spermatozoa, mutual recognition, and binding of gametes mediated by receptors located on the surface membranes of both gametes. The final step is followed by oocyte activation, which is primarily triggered via sperm-derived factors, inducing a More >

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