Guest Editors
Assist. Prof. Wuran Wei
Email: weiwuran@scu.edu.cn
Affiliation: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China
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Research Interests: benign prostatic hyperplasia, kidney tumors, urinary calculi, minimally invasive surgical treatment, male infertility
Dr. Dechao Feng
Email: dechao.feng@ucl.ac.uk
Affiliation: Division of Surgery and' Interventional Science, University College London, London W1W 7TS, UK
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Research Interests: aging and biorhythm, immune-oncology, multi-omics and drugs
Summary
Renal development is a precisely orchestrated process governed by dynamic molecular interactions, from nephrogenesis to ureter maturation. Disruptions in key pathways (e.g., GDNF-RET, Wnt/β-catenin) contribute to congenital anomalies like ureteral atresia and renal dysplasia – common precursors to adult conditions such as ureteroenteric anastomotic strictures. Despite advances in endourology (e.g., autologous bypass-ureteroplasty), high recurrence rates persist due to unresolved molecular drivers of fibrosis and regeneration failure.
To curate translational research elucidating how developmental mechanisms inform the prevention and repair of obstructive uropathies, with emphasis on molecular targets and minimally invasive reconstruction.
We seek contributions that: (1) Decipher molecular drivers of ureteral/kidney development (signalling pathways, epigenetics, cell-matrix interactions). (2) Link developmental errors to acquired pathologies (e.g., fibrosis in anastomotic strictures). (3) Validate regenerative strategies (stem cells, biomaterials, gene editing) in preclinical/clinical models. (4) Optimize surgical techniques (endo-bypass, tissue engineering) using developmental principles. (5) Exclusions: Pure clinical trials without mechanistic insights; non-urological developmental studies.
Suggested themes are listed:
· Molecular Orchestration of Renal Morphogenesis;
· Developmental Errors to Acquired Disease;
· Regenerative Medicine & Surgical Translation;
· Clinical Outcomes & Future Horizons.
Keywords
renal morphogenesis, ureteral obstruction, epigenetic regulation, fibrosis pathogenesis, minimally invasive reconstruction, tissue-engineered scaffolds
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