Guest Editors
Assoc. Prof. Yu-Yan Lan
Email: yyinmed@isu.edu.tw
Affiliation: School of Medicine, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan
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Research Interests: tumor microenvironment, exosome, head and neck cancer, epstein-barr virus, plant extract
Summary
Head and neck cancer (HNC) represents a diverse group of malignancies characterized by complex interactions between tumor cells and their surrounding microenvironment. Accumulating evidence indicates that the tumor microenvironment (TME), including stromal cells, immune cells, extracellular matrix components, and signaling molecules, plays a pivotal role in HNC progression, metastasis, and therapeutic response. Understanding these interactions at the cellular and molecular level is essential for developing effective targeted therapies and improving patient outcomes.
Key areas of focus include but are not limited to:
· Mechanistic studies of cancer-stroma interactions influencing HNC cell proliferation, invasion, and metastasis.
· Regulation of immune cell function and immune evasion mechanisms within the HNC tumor microenvironment.
· Signal transduction pathways mediating cross-talk between tumor cells and TME components.
· Molecular mechanisms underlying angiogenesis, hypoxia, and metabolic reprogramming in HNC.
· Role of extracellular matrix remodeling and cell adhesion molecules in tumor progression.
· Targeted therapeutic strategies addressing TME-driven HNC progression at the cellular level.
· Experimental approaches using cell lines, organoids, and primary cells to dissect TME-related mechanisms.
This Special Issue aims to bring together studies that reveal the cellular and molecular mechanisms by which the tumor microenvironment contributes to head and neck cancer progression. Contributions that combine mechanistic cellular insights with translational relevance will be particularly encouraged, providing a platform for advancing our understanding of HNC biology and developing novel therapeutic strategies.
Keywords
tumor microenvironment, exosome, head and neck cancer, cellular mechanisms, signal transduction, immune evasion, angiogenesis, stromal interaction, metastasis, apoptosis, autophagy, parthanatos, invasion, migration, proliferation
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