Guest Editors
Prof. Dr. Ralf Weiskirchen
Email: rweiskirchen@ukaachen.de
Affiliation: Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), Medical Faculty, RWTH Aachen University, 52074, Aachen, Germany
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Research Interests: TGF-β, PDGF, BMPs, gene therapy, liver pathology, hepatocellular carcinoma, animal models, biomarkers
Summary
Cell signaling is crucial for cellular behavior, development, and adaptation. Our understanding of signaling cascades has grown significantly in recent decades, revealing a complex network of molecular events that control processes such as proliferation, differentiation, apoptosis, immune responses, and metabolic regulation. Disruptions in these pathways can lead to various diseases, including cancer, neurodegeneration, metabolic disorders, and autoimmune conditions. In this context, BIOCELL is inviting contributions to a special issue on "Advanced Cell Signaling Pathways in Health and Disease", aiming to highlight cutting-edge discoveries at the cellular level that illuminate the mechanisms, functions, and therapeutic potentials of signaling networks.
This special issue will concentrate on the latest breakthroughs in deciphering signal transduction mechanisms, focusing on their roles in both physiological and pathological contexts. Subtopics of interest include (but are not limited to):
1. Novel Pathways and Crosstalk Mechanisms: Research exploring newly identified signaling pathways or uncharacterized interactions between canonical pathways like MAPK, PI3K/AKT, Notch, Wnt, or TGF-β, especially in dynamic cellular environments.
2. Spatiotemporal Dynamics of Signaling Events: Studies that reveal how the localization and timing of signaling molecules contribute to specific cellular outcomes, including live-cell imaging studies, biosensor-based analyses, or single-cell signaling heterogeneity.
3. Signaling in Stem Cell Fate and Differentiation: Investigations into how signaling networks guide pluripotency, lineage commitment, or reprogramming, particularly under physiological conditions or during tissue regeneration.
4. Signal Transduction in Immune Surveillance and Inflammation: Articles uncovering how immune cells sense and respond to their microenvironment through complex signaling networks, and how dysregulation leads to chronic inflammation or immune evasion in disease.
5. Oncogenic Signaling Networks: Mechanistic studies of how mutations or epigenetic alterations impact signaling cascades to promote tumor initiation, progression, and resistance to therapy.
6. Targeting Cell Signaling for Therapy: Work focused on pharmacological modulation of signaling pathways, including the development of inhibitors, degraders, or RNA-based therapeutics that operate with cell-specific precision.
By bringing together these diverse aspects of signaling research, this special issue aims to offer a comprehensive platform for understanding how signal transduction influences cellular function and dysfunction. We particularly encourage studies that provide novel mechanistic insights or therapeutic implications based on robust cellular models or systems biology approaches.
Keywords
cell signaling, signal transduction, molecular networks, spatiotemporal dynamics, crosstalk mechanisms, stem cell fate, immune surveillance, oncogenic signaling, metabolic regulation, chronic inflammation, pharmacological modulation, therapeutic targeting, rna-based therapeutics, systems biology approaches, disease models and biomarkers
Published Papers
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