Guest Editors
Associate Professor Jea-Ho Lee
Email: anato82@dsmc.or.kr
Affiliation: Department of Anatomy, Keimyung University School of Medicine, Daegu 42601, Republic of Korea
Homepage:
Research Interests: DNA methylation, histone modifications, non-coding RNAs (miRNA, lncRNA, circRNA), epigenetic regulation, tumor microenvironment, prognostic and diagnostic biomarkers
Assistant Professor Jongwan Kim
Email: dahyun@dongguk.ac.kr
Affiliation: Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea
Research Interests: DNA methylation, histone modifications, non-coding RNAs, epigenetic regulation in cancer, biomarker discovery and validation, tumor immune microenvironment, prognostic and diagnostic biomarkers, exosomal ncRNAs
Summary
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic modifications and non-coding RNAs (ncRNAs). DNA methylation, histone modifications, chromatin remodeling, and ncRNAs such as microRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as critical regulators of gene expression and cellular behavior in cancer. Importantly, these molecules hold great potential as diagnostic and prognostic biomarkers, yet their clinical utility requires a deeper mechanistic understanding at the cellular level.
This Special Issue aims to bring together high-quality original research and comprehensive reviews that explore the cellular mechanisms by which epigenetic modifications and ncRNAs regulate cancer initiation, progression, and therapeutic response. Submissions should emphasize mechanistic insights at the cellular or subcellular level, in line with the scope of BIOCELL. Studies combining molecular biology, cell biology, and translational perspectives are particularly encouraged.
Topics of interest include, but are not limited to:
- Mechanistic roles of ncRNAs (miRNAs, lncRNAs, circRNAs) in regulating cancer cell proliferation, apoptosis, autophagy, migration, invasion, and differentiation.
- Epigenetic regulation of oncogenes and tumor suppressors in cancer cells, including DNA methylation, histone modifications, and chromatin remodeling.
- Interactions between epigenetic modifications and ncRNAs in modulating signaling pathways within cancer cells.
- ncRNA- and epigenetic-mediated regulation of cancer cell stemness, metabolic reprogramming, and drug resistance.
- Identification and validation of epigenetic and ncRNA biomarkers in cancer, with supporting cellular and molecular evidence.
- Integration of single-cell and multi-omics approaches with cellular functional assays to reveal biomarker-associated mechanisms.
- Animal model and clinical studies that confirm or validate mechanisms uncovered at the cellular level.
By highlighting the interplay between epigenetic regulation, non-coding RNAs, and cancer cell behavior, this Special Issue seeks to provide new mechanistic insights and translational perspectives. We welcome contributions that bridge molecular alterations to cellular functions, aiming to advance the development of reliable biomarkers for early diagnosis, prognosis, and personalized therapy in cancer.
Keywords
epigenetics, non-coding RNA, Immune cell infiltration, Prognostic biomarker, Drug sensitivity and Resistance, cellular mechanism, apoptosis, proliferation, migration, signal transduction
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