Guest Editors
Prof. Da-Tian Bau
Email: artbau2@gmail.com
Affiliation: Graduate Institute of Biomedical Sciences, China Medical University, 404333, Taichung, Taiwan
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Research Interests: cancer genomics, translational medical sciences, personalized genomic and pharmaceutical sciences, DNA damage and repair, cell physiology, cell toxicology
Summary
Cancer arises from complex interactions between genetic variations and cellular behaviors. While genetic alterations are well documented in tumor development, the underlying cellular and molecular mechanisms by which these variations drive oncogenic phenotypes remain incompletely understood. This special issue aims to provide a platform for studies that dissect the mechanistic links from genotypic variations to cellular phenotypes in carcinogenesis.
This special issue encourages submissions that focus on cell-level mechanistic exploration of cancer-related genetic variations. Contributions may include, but are not limited to:
· Genetic variations regulating cellular signaling pathways
· Studies exploring how gene mutations, copy number variations, or epigenetic modifications modulate signaling pathways such as p53, PI3K/AKT, MAPK, and Wnt/β-catenin at the cellular level.
· Impact of genotypic changes on cellular functions
· Mechanistic investigations of how specific genetic alterations influence proliferation, apoptosis, autophagy, migration, invasion, and differentiation.
· Use of gene-editing or gene-silencing technologies (e.g., CRISPR, siRNA, shRNA) is highly encouraged to validate functional effects.
· Molecular interactions shaping cellular phenotypes
· Analyses of protein–protein interactions, transcriptional regulation, or signaling networks driven by genetic variations and their effects on cellular behavior.
· Techniques may include co-immunoprecipitation, immunofluorescence, colocalization, or single-cell RNA sequencing.
· Tumor microenvironment and cell-level mechanisms
· Studies addressing how cancer cells interact with immune or stromal cells, provided the work clarifies cellular mechanisms rather than solely reporting tissue-level observations.
· Mechanism-based therapeutic interventions
· Investigations of drugs or small molecules targeting specific genetic variants or pathways, with a clear explanation of cellular-level mechanisms underlying therapeutic effects.
This special issue provides a platform for innovative and mechanistically rigorous studies connecting genotype to phenotype at the cellular level, advancing our understanding of carcinogenesis and potential therapeutic strategies.
Keywords
genetic variations, cellular mechanisms, carcinogenesis, signal transduction, cell proliferation, apoptosis, molecular interactions, tumor microenvironment
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