Guest Editors
Prof. Dr. Jing-Hua Wang
Email: wjhdon@dongguk.edu
Affiliation: Institute of Oriental Medicine, Dongguk University, 32 Dongguk-ro, Goyang, Gyeonggi-do 10326, Republic of Korea
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Research Interests: gut microbiome, microbial metabolites, hepatic diseases, aging, sarcopenia, osteoporosis
Prof. Dr. Mukesh Kumar Yadav
Email: mukesh.yadav@cup.edu.in
Affiliation: Department of Microbiology, Central University of Punjab, Bathinda-151001, India
Homepage:
Research Interests: medical microbiology, host-pathogen interaction, microbial pathogenesis, drug discovery, molecular diagnostics
Summary
Aging is characterized by profound physiological alterations that predispose individuals to chronic conditions such as sarcopenia and osteoporosis, which represent major contributors to frailty and disability in the elderly population. Increasing evidence highlights the central role of the gut–liver axis, particularly the enterohepatic circulation of bile acids and the gut microbiome, in regulating musculoskeletal health during aging.
This Special Issue will place a particular emphasis on molecular and cellular mechanisms. We encourage submissions that investigate how microbiota-derived metabolites and the activation of receptors (e.g., FXR, TGR5, GPRs) regulate signaling pathways in myoblasts, osteoblasts, osteoclasts, and immune cells. Studies elucidating key aging-related cellular processes, including apoptosis, autophagy, differentiation, senescence, mitochondrial dysfunction, and metabolic reprogramming, are especially welcome.
By bridging systemic observations with cellular mechanistic validation, this Special Issue aims to provide an interdisciplinary platform to advance our understanding of how the enterohepatic circulation and gut microbiome contribute to the pathophysiology of sarcopenia and osteoporosis in aging populations. We invite a broad spectrum of contributions, including original research articles, comprehensive reviews, mini-reviews, perspectives highlighting emerging concepts, and methodological studies that introduce novel experimental or analytical approaches.
Topics of interest include, but are not limited to:
· Mechanistic insights into bile acid metabolism and receptor-mediated signaling in muscle, bone, and immune cells during aging
· Cellular effects of microbiota-derived metabolites (e.g., SCFAs, tryptophan derivatives) on apoptosis, autophagy, and differentiation
· Crosstalk between gut–liver–muscle–bone axis at the molecular, cellular, and systemic levels
· Omics-based approaches (metagenomics, metabolomics, transcriptomics) linking microbiota functions to cellular pathways
· Preclinical and clinical studies that connect systemic observations with cellular-level mechanistic validation
· Probiotics, herbal medicine, and dietary interventions modulating bile acid– microbiome dynamics, with mechanistic insights into cellular targets
· Biomarkers and predictive models for musculoskeletal health linked to the gut–liver axis
Keywords
gut microbiome, microbial metabolite, cellular signaling, aging, sarcopenia, osteoporosis, enterohepatic circulation, probiotics, gut-liver-muscle-bone axis
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