Guest Editors
Dr. Carlo Acierno
Email: carlo894@gmail.com
Affiliation: Department of Infectious Diseases, Azienda Ospedaliera Regionale San Carlo, 85100 Potenza, Italy
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Research Interests: gut microbiota, oxidative stress, inflammation, metabolic diseases, infectious diseases, cellular signaling, microbial metabolites, hostmicrobiome interactions
Summary
The gut microbiota, oxidative stress, and inflammation are crucial factors influencing both health and disease. Emerging research has revealed the intricate interplay between these elements and their significant roles in metabolic and infectious diseases. The gut microbiota, through its diverse microbial populations, directly affects host immune functions, metabolic processes, and cellular activities. Disruptions to the balance of this microbiota, known as dysbiosis, have been linked to various chronic diseases, including obesity, diabetes, non-alcoholic fatty liver disease, and inflammatory bowel diseases.
This special issue seeks to explore the cellular and molecular mechanisms that govern the interactions between the gut microbiota, oxidative stress, and inflammation, and their collective impact on metabolic and infectious diseases. We invite both original research and review articles that address the following key topics:
1. Regulation of Host Cellular Functions by Gut Microbiota
- Investigating how gut microbiota modulates host cell signaling, immune responses, and metabolic pathways.
- Exploring the molecular mechanisms through which microbial metabolites influence cellular functions.
2. Mechanisms of Oxidative Stress in Driving Inflammation and Cellular Damage
- Understanding how oxidative stress induces inflammatory pathways and contributes to cellular injury.
- Examining the link between oxidative damage and disease processes in metabolic and infectious diseases.
3. Impact of Microbial Metabolites on Cellular Signaling Pathways and Disease Progression
- Studying how microbial metabolites, such as short-chain fatty acids (SCFAs) and lipopolysaccharides, influence host signaling pathways.
- Assessing the role of microbial metabolites in modulating immune responses and promoting disease progression.
4. Cellular Mechanisms of Inflammation in Metabolic Diseases (e.g., Diabetes, Obesity)
- Delving into the pathways through which inflammation contributes to metabolic disruptions like insulin resistance and obesity.
- Understanding the interaction between oxidative stress, gut microbiota, and inflammation in the pathogenesis of metabolic diseases.
5. Gut Microbiota-Host Interactions in Infectious Diseases
- Exploring the influence of gut microbiota on immune responses during infection.
- Understanding how microbial imbalances contribute to altered susceptibility to infections and the severity of disease.
6. Antioxidant Strategies in Modulating Inflammation and Metabolic Disorders
- Investigating the role of antioxidants in mitigating oxidative stress and reducing inflammation in metabolic diseases.
- Evaluating the therapeutic potential of antioxidants in treating diseases related to oxidative stress and inflammation.
7. Novel Therapeutic Approaches Targeting Gut Microbiota, Oxidative Stress, or Inflammation
- Exploring cutting-edge therapies aimed at modulating the gut microbiota, oxidative stress, or inflammatory pathways for disease management.
- Investigating personalized approaches that could leverage microbiome, oxidative stress, or inflammation as therapeutic targets in metabolic and infectious diseases.
The aim of this special issue is to present a comprehensive view of the latest advances in understanding how gut microbiota, oxidative stress, and inflammation intersect to influence human health and disease. This issue will provide insights into the complex mechanisms at play and highlight emerging therapeutic strategies that target these pathways for the prevention and treatment of diseases. By addressing both metabolic and infectious diseases, this special issue will offer a multidimensional approach to understanding disease pathophysiology from the cellular and molecular levels.
Keywords
gut microbiota, oxidative stress, inflammation, metabolic diseases, infectious diseases, cellular mechanisms, microbial metabolites, therapeutic strategies
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