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MicroRNA as Biomarkers for Disease Diagnosis and Progression

Submission Deadline: 31 May 2024 Submit to Special Issue

Guest Editors


Prof. Nimanthi Jayathilaka, Department of Chemistry, Faculty of Science, University of Kelaniya, Sri Lanka. njayathi@kln.ac.lk

Summary

MicroRNAs (miRNAs) regulate numerous developmental and physiological processes via transcriptional regulation. These small, non-coding RNAs of 17-25 nucleotides account for 1-3 % of the mammalian genome with approximately 2600 mature miRNAs reported to date. MiRNAs regulate cellular functions and gene expression networks by either repressing translation or subjecting target mRNAs to degradation. Therefore, miRNAs show aberrant expression during the development of infectious and non-infectious diseases and disease progression. These aberrantly expressed miRNAs can be utilized as a diagnosis strategy for diseases. As such, there is high interest in investigating the regulatory functions of miRNA and the role of those miRNAs as biomarkers for disease diagnosis. However, such studies are at times limited to a small subset of miRNAs and are hampered by limited available literature. While the detection of a small number of miRNAs may provide more insight into the molecular mechanisms involved in regulatory gene expression networks and disease progression, high throughput bioinformatics analysis may reveal more robust biomarker candidates for disease diagnosis and prognosis.

 

This special issue on “MicroRNA as biomarkers for disease diagnosis and progression” invites submission of original papers and review articles that focus on the emerging role of miRNAs in the diagnosis and prognosis of infectious and non-infectious diseases such as viral and bacterial infections, diabetes, cardiovascular diseases, neuromuscular disorders, and cancer using biological and computational analysis as well as clinical investigations.

 

Areas of interest include, but are not limited to:

1) MiRNAs as biomarkers in the development of infectious or non-infectious diseases.

2) MiRNAs as biomarkers for disease diagnosis in infectious or non-infectious diseases.

3) MiRNAs as biomarkers for the prognosis of infectious or non-infectious diseases.

4) MiRNAs in disease progression in infectious or non-infectious diseases.

5) Molecular mechanism of miRNAs in developing and progressing infectious or non-infectious diseases.

6) Molecular mechanism of miRNAs in the severity of infection or disease progression in non-infectious diseases.

7) Bioinformatic analysis of miRNAs in diagnosis and prognosis of infectious or non-infectious diseases.

8) Systemic review and meta-analysis of miRNAs in infectious and non-infectious disease diagnosis and prognosis


Keywords

microRNA, Biomarker, Diagnosis, Prognosis, Infectious Diseases, Non-Infectious Diseases

Published Papers


  • Open Access

    ARTICLE

    Circular RNA circ_0003609 ameliorates hypertrophied ligamentum flavum by regulating the miR-155/SIRT1 axis

    GUIBIN ZHONG, SHURONG WANG, YUJIN HE, DAMING FENG, KE WEI, YANQIU YANG, JIANWEI CHEN, JUNLING CHEN
    BIOCELL, DOI:10.32604/biocell.2024.050294
    (This article belongs to the Special Issue: MicroRNA as Biomarkers for Disease Diagnosis and Progression)
    Abstract Background: Hypertrophy of the ligamentum flavum (HLF) is a common contributor to spinal stenosis which results in significant neurological impairments. Circular RNA (circRNA) circ_0003609 has been linked to HLF; however, the exact mechanism by which it causes this disease is unclear. Methods: Circ_0003609 expressions were regulated in HLF cells by overexpression vectors and RNA interference. Cell proliferation and fibrosis-related gene expression were checked by the Cell Counting Kit-8 (CCK-8) assay and western blotting. CircBank’s prediction of the association between miR-155 and circ_0003609 was supported by a dual-luciferase reporter experiment. The function of the miR- 155/sirtuin 1 More >

  • Open Access

    ARTICLE

    Knockdown of circular RNA (CircRNA)_001896 inhibits cervical cancer proliferation and stemness in vivo and in vitro

    JIA SHAO, CAN ZHANG, YAONAN TANG, AIQIN HE, WEIPEI ZHU
    BIOCELL, Vol.48, No.4, pp. 571-580, 2024, DOI:10.32604/biocell.2024.049092
    (This article belongs to the Special Issue: MicroRNA as Biomarkers for Disease Diagnosis and Progression)
    Abstract Objective: Previous studies indicated that aberrant circular RNA (circRNA) expression affects gene expression regulatory networks, leading to the aberrant activation of tumor pathways and promoting tumor cell growth. However, the expression, clinical significance, and effects on cell propagation, invasion, and dissemination of circRNA_001896 in cervical cancer (CC) tissues remain unclear. Methods: The Gene Expression Omnibus (GEO) datasets (GSE113696 and GSE102686) were used to examine differential circRNA expression in CC and adjacent tissues. The expression of circRNA_001896 was detected in 72 CC patients using fluorescence quantitative PCR. Correlation analysis with clinical pathological features was performed through… More >

  • Open Access

    ARTICLE

    miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

    LIJUAN ZHANG, QINGYIN MENG, LI ZHUANG, QUAN GONG, XIANDA HUANG, XUEQIN LI, SHIJUAN LI, GUOQIN WANG, XICAI WANG
    BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260
    (This article belongs to the Special Issue: MicroRNA as Biomarkers for Disease Diagnosis and Progression)
    Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells.… More >

    Graphic Abstract

    miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

  • Open Access

    REVIEW

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

    CAIJUAN LIU, XINGHAO LI, YUXUAN WU, JINHUI YANG, MENGHAN WANG, YUNQI MA
    BIOCELL, Vol.48, No.3, pp. 387-401, 2024, DOI:10.32604/biocell.2024.048791
    (This article belongs to the Special Issue: MicroRNA as Biomarkers for Disease Diagnosis and Progression)
    Abstract Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is the most malignant and still has no cure. However, the novel role of long non-coding RNAs (lncRNAs) in the pathogenesis of glioblastoma is attracting extensive attention. LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins. Unlike small non-coding RNAs, such as microRNAs (miRNAs), lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA, RNA, and proteins and perform multiple regulatory functions. LncRNAs act as molecular sponges, absorbing and sequestering other biomolecules,… More >

    Graphic Abstract

    LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

  • Open Access

    ARTICLE

    MiR-30a-5p alleviates LPS-induced HPMEC injury through regulation of autophagy via Beclin-1

    RAN PAN, JIAYAN MAO, YUELIANG ZHENG, WEI CHEN, JUNPING GUO, LIJUN WANG
    BIOCELL, Vol.48, No.3, pp. 431-441, 2024, DOI:10.32604/biocell.2023.046484
    (This article belongs to the Special Issue: MicroRNA as Biomarkers for Disease Diagnosis and Progression)
    Abstract Background: Sepsis, a type of systemic disease, can impact nearly all organs, tissues and cells. Among them, endothelial cells are amongst the first to be affected and respond to the insult. In this study, we investigated the protective effects of microRNA-30a-5p (miR-30a-5p) on human pulmonary microvascular endothelial cells (HPMECs) treated with lipolysaccharide (LPS). Methods: An in vitro model of sepsis was established in HPMECs with the use of LPS. Transfecting with different tools (mimetic and inhibitor) to modify miR-30a-5p expression. Cell viability, proliferation and apoptosis were detected by the CCK-8 assay, the EdU kit and fluorescence… More >

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