Guest Editors
Dr. Yang Yang
Email: yangyangbio@163.com
Affiliation: Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
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Research Interests: microtubule-associated proteins, cardiac development, vesicular transport, mitochondria, cardiac remodeling, heart failure mechanisms, therapeutic targets in cardiovascular disease
Dr. Kaidi Ren
Email: Renkd006@163.com
Affiliation: Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
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Research Interests: MAMs, mitochondria, tumor growth and metastasis mechanisms, therapeutic targets in tumors
Summary
Mitochondria-Associated Membranes (MAMs) and Human Disease
This Special Issue aims to bring together cutting-edge research and comprehensive reviews that advance our understanding of mitochondria-associated membranes (MAMs) as a critical platform for inter-organelle communication. MAMs serve as hubs linking mitochondria with the endoplasmic reticulum, thereby regulating diverse cellular processes including calcium signaling, lipid metabolism, autophagy, apoptosis, and innate immune responses. Given their pivotal role, aberrant MAM dynamics have been increasingly implicated in the pathogenesis of a wide range of human diseases. The goal of this issue is to highlight novel molecular mechanisms, emerging experimental models, and translational opportunities that deepen insight into MAM biology and its relevance to disease.
Scope
We welcome original research articles, reviews, and perspectives that address the role of MAMs in human health and disease. Topics of interest include, but are not limited to: MAM regulation of metabolic homeostasis and neurodegeneration; MAM dysfunction in cardiovascular, oncologic, and inflammatory disorders; MAM-associated mechanisms in mitochondrial dynamics, ER stress, and cell death pathways; novel imaging and omics-based approaches to study MAMs; and therapeutic strategies targeting MAMs for disease intervention. Submissions spanning fundamental biology, clinical research, and translational applications are encouraged, with an emphasis on interdisciplinary approaches that connect molecular insights with pathophysiological outcomes.
Keywords
mitochondria-associated membranes, calcium signaling, lipid metabolism, endoplasmic reticulum-mitochondria crosstalk, human disease
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