Guest Editors
Dr. Abdellah Baraich
Email: abdellah.baraich@ump.ac.ma
Affiliation: Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health (LBBES), Faculty of Sciences, Mohammed First University, Oujda, 60000, Morocco
Homepage:
Research Interests: genotoxicity, oxidative stress, secondary metabolites
Prof. Ennouamane Saalaoui
Email: e.saalaoui@ump.ac.ma
Affiliation: Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health (LBBES), Faculty of Sciences, Mohammed First University, Oujda, 60000, Morocco
Homepage:
Research Interests: genotoxicity assays, plant biochemistry
Dr. Amine Elbouzidi
Email: amine.elbouzidi@ump.ac.ma
Affiliation: LAPABE Laboratory, Mohammed First University, Oujda, 60000, Morocco
Homepage:
Research Interests: plant biotechnology, phytoremediation
Summary
This special issue aims to explore the genotoxic effects of xenobiotics (e.g., pesticides, heavy metals, industrial pollutants) and the protective mechanisms offered by medicinal and aromatic plants. We welcome original research and reviews addressing the following themes:
1. Mechanisms of Xenobiotic-Induced Genotoxicity
· Oxidative stress
· DNA alterations (single/double strand breaks, crosslinks, mutations)
· Epigenetic modifications induced by xenobiotic exposure
2. Modern Evaluation Tools
· In vitro and in vivo genotoxicity assays (Comet assay, SCD, TUNEL, SCSA, micronucleus, Ames test)
· Molecular and cellular biomarkers
· Omics approaches (genomics, transcriptomics)
3. Protective Role of Plants
· Mechanisms of action of secondary metabolites (polyphenols, alkaloids, terpenoids)
· Studies on medicinal plant species
· Applications in phytoremediation and human health
4. Biotechnological Perspectives
· CRISPR-based gene editing technologies
· Plant cell cultures
· Innovative models for sustainable solutions
Keywords
genotoxicity, comet/SCD/TUNEL assays, medicinal plants, oxidative stress, bioremediation, Morocco, xenobiotics