Special Issues
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Genotoxicity and Genoprotection of Xenobiotic Compounds: The Role of Plants and Modern Evaluation Tools

Submission Deadline: 01 April 2026 View: 468 Submit to Special Issue

Guest Editors

Dr. Abdellah Baraich

Email: abdellah.baraich@ump.ac.ma

Affiliation: Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health (LBBES), Faculty of Sciences, Mohammed First University, Oujda, 60000, Morocco

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Research Interests: genotoxicity, oxidative stress, secondary metabolites


Prof. Ennouamane Saalaoui

Email: e.saalaoui@ump.ac.ma

Affiliation: Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health (LBBES), Faculty of Sciences, Mohammed First University, Oujda, 60000, Morocco

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Research Interests: genotoxicity assays, plant biochemistry


Dr. Amine Elbouzidi

Email: amine.elbouzidi@ump.ac.ma

Affiliation: LAPABE Laboratory, Mohammed First University, Oujda, 60000, Morocco

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Research Interests: plant biotechnology, phytoremediation


Summary

This special issue aims to explore the genotoxic effects of xenobiotics (e.g., pesticides, heavy metals, industrial pollutants) and the protective mechanisms offered by medicinal and aromatic plants. We welcome original research and reviews addressing the following themes:

1. Mechanisms of Xenobiotic-Induced Genotoxicity
· Oxidative stress
· DNA alterations (single/double strand breaks, crosslinks, mutations)
· Epigenetic modifications induced by xenobiotic exposure
2. Modern Evaluation Tools
· In vitro and in vivo genotoxicity assays (Comet assay, SCD, TUNEL, SCSA, micronucleus, Ames test)
· Molecular and cellular biomarkers
· Omics approaches (genomics, transcriptomics)
3. Protective Role of Plants
· Mechanisms of action of secondary metabolites (polyphenols, alkaloids, terpenoids)
· Studies on medicinal plant species
· Applications in phytoremediation and human health
4. Biotechnological Perspectives
· CRISPR-based gene editing technologies
· Plant cell cultures
· Innovative models for sustainable solutions


Keywords

genotoxicity, comet/SCD/TUNEL assays, medicinal plants, oxidative stress, bioremediation, Morocco, xenobiotics

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