Special Issues
Table of Content

Understanding Cellular Mechanisms in Wound Healing During Therapeutic Interventions

Submission Deadline: 28 April 2025 (closed) View: 1661 Submit to Journal

Guest Editors

Dr. Stefano Bacci

Email: stefano.bacci@unifi.it 

Affiliation: Research Unit of Histology and Embriology, Department of Biology, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy.

Homepage: 

Research Interests: mast cells, dendritic cells, cellular infiltrate, wound healing, acute wounds, chronic wounds. photobioomodulation, drug

图片2.png


Summary

Wound healing is a complex biological process involving multiple cellular mechanisms that are crucial for tissue repair and regeneration. This special issue aims to delve into the cellular mechanisms underlying wound repair, with a focus on how various therapeutic interventions influence these processes.

 

By compiling pioneering research from leading experts in the field, this issue seeks to illuminate novel insights and therapeutic avenues in wound healing. Key areas of focus include but are not limited to:

1. Cellular Mechanisms in Wound Repair:

-Investigating the roles of different cell types (e.g., fibroblasts, immune cells, stem cells) in the wound healing process.

-Understanding how cellular behaviors such as migration, proliferation, and differentiation contribute to tissue repair.

2. Impact of Therapeutic Interventions on Wound Healing:

-Exploring how various treatments (e.g., drug therapies, gene therapies, cell therapies) alter cellular mechanisms during wound repair.

-Examining the efficacy and mechanisms of emerging therapeutic approaches in enhancing wound healing.

3. Signaling Pathways in Wound Healing:

-Analyzing how specific signaling pathways regulate cellular functions and interactions in the context of wound repair.

-Identifying potential targets for therapeutic intervention based on signaling pathway modulation.

4. Extracellular Matrix and Wound Healing:

-Investigating the role of the extracellular matrix in supporting cellular functions and facilitating wound repair.

-Exploring how modifications to the extracellular matrix influence the healing process.

5. Biomarkers and Assessment of Wound Healing:

-Identifying biomarkers that reflect the progress and effectiveness of wound healing interventions.

-Discussing challenges and advancements in biomarker discovery and application for assessing wound healing outcomes.

 

Through this special issue, we aim to foster interdisciplinary collaboration and advance our understanding of the cellular mechanisms driving wound repair in response to therapeutic interventions. We welcome original research articles, comprehensive reviews, and perspectives that explore the dynamic interactions between cellular mechanisms and therapeutic strategies in wound healing. By highlighting the latest discoveries and ongoing challenges, this issue aspires to contribute to the development of more effective treatments and personalized approaches for wound management.


Keywords

mast cells, dendritic cells, cellular infiltrate, wound healing, acute wounds, chronic wounds. photobioomodulation, drug

Published Papers


  • Open Access

    COMMENTARY

    Exendin-4 and Wound Healing

    Stefano Bacci
    BIOCELL, Vol.49, No.11, pp. 2137-2145, 2025, DOI:10.32604/biocell.2025.069216
    (This article belongs to the Special Issue: Understanding Cellular Mechanisms in Wound Healing During Therapeutic Interventions)
    Abstract This commentary analyzes the effect of Exendin-4 on wound healing. After introducing information about the drug, considerations are added regarding its impact on this process. To accelerate wound healing, the drug’s combined effects with stem cells and other factors are examined, aiming to enhance and thus accelerate the process. Finally, the clinical potential of this drug’s effect is considered, not only for wound healing but also in other diseases. Therefore, reading this commentary may provide research perspectives that can stimulate the future reader’s thinking. More >

  • Open Access

    REVIEW

    Malignant Transformation of Diabetic Foot Ulcer: Pathophysiology, Molecular Mechanisms, and Clinical Implications

    Sophia Strukel, Vikrant Rai
    BIOCELL, Vol.49, No.10, pp. 1887-1911, 2025, DOI:10.32604/biocell.2025.067207
    (This article belongs to the Special Issue: Understanding Cellular Mechanisms in Wound Healing During Therapeutic Interventions)
    Abstract Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus and are associated with high morbidity, risk of amputation, and increased mortality. Although DFUs typically remain a chronic, non-healing wound, a small portion of DFUs may undergo malignant transformation. The subsequent malignancies are skin cancers such as squamous cell carcinoma (SCC), basal cell carcinoma, or melanoma. Understanding the pathophysiology of DFUs and the molecular and clinical determinants that contribute to their potential malignant transformation if crucial for clinical management. Chronic inflammation, dysregulation of cytokine signaling, faulty immune surveillance, and impaired wound healing all play… More >

  • Open Access

    ARTICLE

    Human-Derived Low-Molecular-Weight Protamine (hLMWP) Conjugates Enhance Skin Cell Penetration and Physiological Activity

    Seo Yeon Shin, Nu Ri Song, Sa Rang Choi, Ki Min Kim, Jae Hee Byun, Su Jung Kim, Dai Hyun Jung, Seong Sim Kim, Seong Ju Park, So Jeong Chu, Kyung Mok Park
    BIOCELL, Vol.49, No.8, pp. 1435-1448, 2025, DOI:10.32604/biocell.2025.065199
    (This article belongs to the Special Issue: Understanding Cellular Mechanisms in Wound Healing During Therapeutic Interventions)
    Abstract Background: The efficient transdermal delivery of biologically active molecules remains a major challenge because of the structural barrier of the stratum corneum, which limits the penetration of large or hydrophilic molecules. Low-molecular-weight protamine (LMWP) has a structure similar to that of the HIV TAT protein-derived peptide and is a representative cell-penetrating peptide (CPP) used to increase cell permeability. However, protamine has been reported to have many toxicities and side effects. Objectives: We developed human-derived low-molecular-weight protamine (hLMWP), which is based on fish-derived LMWP but designed using human protein sequences to improve safety and functionality. As… More >

    Graphic Abstract

    Human-Derived Low-Molecular-Weight Protamine (hLMWP) Conjugates Enhance Skin Cell Penetration and Physiological Activity

  • Open Access

    ARTICLE

    Effects of Exendin-4 on diabetic wounds: Direct action on proliferative phase of wound healing

    VIRGINIA LOTTI, GAETANO DE SIENA, STEFANO BACCI
    BIOCELL, Vol.48, No.12, pp. 1751-1759, 2024, DOI:10.32604/biocell.2024.057904
    (This article belongs to the Special Issue: Understanding Cellular Mechanisms in Wound Healing During Therapeutic Interventions)
    Abstract Background: Impaired wound healing is one of the most well-known complications of type 2 diabetes mellitus. Experimental evidence suggested that treatment with Exendin-4, a glucagon-like peptide-1 agonist displaying a wide range of antidiabetic effects, can promote tissue regeneration. Objectives: Thus, this study aimed to examine the efficacy of topical treatment with Exendin-4 in accelerating wound healing in normoglycemic and hyperglycemic mice. Methods: For this purpose, two wounds inflicted on the back skin of 12 normo- and 12 hyperglycemic mice were injected intradermally with either saline solution or Exendin-4. Wounds were collected at the time of abrasion… More >

Share Link