Guest Editors
Dr. Srinivasa Reddy Bonam
Email: bsrpharmacy90@gmail.com
Affiliation: Vaccine Immunology Laboratory, Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, 500007, Hyderabad, India
Homepage:
Research Interests: inflammatory diseases, drug discovery, cell-based therapies, molecular mechanisms, humanized mouse models, and autophagy
Dr. Magali Humbert
Email: magali.humbert@yahoo.fr
Affiliation: HemostOD SA, EPFL Innovation Park, 1025 St Sulpice, VD, Switzerland
Homepage:
Research Interests: leukemia, platelets, megakaryocytes, autophagy, and differentiation therapy
Summary
Inflammatory diseases encompass a broad range of disorders characterized by dysregulated immune responses and persistent tissue inflammation. While progress has been made in therapeutic interventions, many inflammatory conditions remain difficult to treat due to their complex pathogenesis at the cellular and molecular levels.
This special issue of BIOCELL aims to bring together cutting-edge research that explores novel strategies to target inflammatory diseases, with a specific emphasis on cellular processes and intracellular regulatory mechanisms such as autophagy, cell death pathways, and organelle stress responses.
We invite contributions that unravel how autophagy and related cellular systems participate in the initiation, amplification, or resolution of inflammation. Manuscripts addressing how these mechanisms are harnessed or modulated by innovative therapeutic approaches—ranging from small molecules and biologics to genetic and nanomedicine-based strategies—are particularly encouraged.
Topics of Interest (include but are not limited to):
· Role of autophagy in innate and adaptive immune responses during inflammation
· Crosstalk between autophagy and inflammatory signaling (e.g., NF-κB, NLRP3 inflammasome)
· Autophagy as a therapeutic target in autoimmune or chronic inflammatory diseases
· Novel anti-inflammatory agents modulating autophagic flux
· Interplay between autophagy, apoptosis, pyroptosis, and other cell stress responses
· Intracellular trafficking, lysosomal dynamics, and organelle communication in inflammation
· Nanotechnology and gene therapy tools targeting cellular homeostasis pathways
· Animal and 3D models for studying autophagy-inflammation interactions
Keywords
inflammatory diseases, autophagy, cellular signaling pathways, immune regulation, molecular mechanisms, therapeutic targets, cell stress responses, innate and adaptive immunity
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