Guest Editors
Dr. Mikhail V. Dubinin
Email: dubinin1989@gmail.com
Affiliation: Department of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, Yoshkar-Ola 424001, Russia
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Research Interests: muscles, ion homeostasis, calcium, myopathy, diabetes, oxidative stress, mitochondria
Prof. Dr. Konstantin N. Belosludtsev
Email: bekonik@gmail.com
Affiliation: Laboratory of Mitochondrial Transport, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia
Homepage:
Research Interests: mitochondria, biophysics, diabetes mellitus, myopathy, mitochondrial Ca2+ transport, reactive oxygen species, lipids
Summary
Mitochondria play a crucial role in the pathogenesis of a wide range of diseases, from metabolic disorders to neuromuscular conditions. This special issue aims to delve into the complex mechanisms by which mitochondrial dysfunction contributes to these diseases, with a particular focus on diabetes, muscular dystrophies, and neurodegenerative pathologies.
By bringing together groundbreaking research from leading experts, this issue seeks to illuminate novel pathways and therapeutic approaches that target mitochondrial function. Key areas of focus include but are not limited to:
1. Mitochondria in Metabolic Disorders:
- Investigating how mitochondrial dysfunction drives insulin resistance and β-cell failure in diabetes.
- Understanding the role of mitochondrial energy metabolism in the development and complications of metabolic diseases.
2. Mitochondrial Dysfunction in Neuromuscular Diseases:
- Exploring the structural and functional changes in mitochondria in congenital and acquired muscular dystrophies and cardiomyopathies.
- Evaluating potential therapies aimed at restoring mitochondrial function in these conditions.
3. Oxidative Stress and ROS in Disease Progression:
- Assessing the impact of mitochondrial-generated reactive oxygen species (ROS) on cellular damage and disease progression.
- Investigating antioxidant strategies to mitigate oxidative stress in metabolic and neuromuscular diseases.
4. Calcium Signaling and Mitochondrial Dysregulation:
- Examining the role of calcium homeostasis in mitochondrial dysfunction, particularly in muscle and cardiac tissues.
- Identifying potential therapeutic targets within calcium signaling pathways to improve mitochondrial health.
5. Energy Metabolism and Disease Development:
- Uncovering how disruptions in mitochondrial energy production contribute to the pathogenesis of both common and rare diseases.
- Highlighting novel metabolic interventions to correct mitochondrial dysfunction.
6. Innovative Therapeutic Approaches Targeting Mitochondria:
- Developing gene therapies, pharmacological treatments, and mitochondrial transplantation strategies to enhance mitochondrial function.
- Exploring new approaches to modulate mitochondrial activity and improve disease outcomes.
Through this special issue, we aim to foster interdisciplinary research and advance our understanding of mitochondrial involvement in various diseases. We welcome original research articles, comprehensive reviews, and perspectives that investigate the multifaceted roles of mitochondria in disease mechanisms and therapeutic innovation. By showcasing the latest discoveries and addressing the challenges in the field, this issue aspires to pave the way for novel treatments and improved patient outcomes.
Keywords
mitochondria, metabolic disorders, neuromuscular diseases, diabetes, muscular dystrophies, cardiomyopathies, oxidative stress, ROS, calcium signaling, energy metabolism, therapeutic strategies
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