Special lssues
Table of Content

Molecular and Cellular Nanobiotechnology

Submission Deadline: 30 December 2021 (closed)

Guest Editors


Dr. Ebrahim Mostafavi, Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; School of Medicine, Stanford University, Stanford, CA, USA.


Dr. Elham Mohit, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: el_mohit@yahoo.com


Dr. Atieh Hashemi Soltanieh, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: at_hashemi@sbmu.ac.ir


Prof. Hossein Vahidi, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: h.vahidi@sbmu.ac.ir


Dr. Hamed Barabadi, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: barabadi@sbmu.ac.ir

Summary

Nanobiotechnology provides a promising chance to develop new materials and methods that could enhance our fundamental understanding of the interactions of nanomaterials with intracellular structures, the process, and the environment. Significantly, developing biosynthesized nanoparticles for pharmaceutical and biological applications is an important objective in nanobiotechnology. The majority of available research in this line has been focused on biological synthesis of metal nanoparticles (MNPs) such as silver and gold nanoparticles by employing natural resources including natural biomolecules, bacteria, yeasts, fungi, plants, algae, photosynthetic organisms, and marine organisms as greener and more environmentally-friendly processes in comparison to traditional physicochemical routes for MNPs synthesis. The dual role of enzymes and biomolecules as reducing and stabilizing agents for biosynthesis of MNPs has been demonstrated. Biological synthesized MNPs have emerged as new tools that can be used for a wide range of biological activities such as antibacterial, antifungal, antiviral, anticancer, antidiabetic, antiparasitic, and anti-inflammatory activities.

 

This special issue will focus on the novel findings and recent researches and developments in bio-based synthesis of MNPs as emerging bioactive agents from molecular to cellular levels. We invite authors to submit a wide range of manuscripts, including experimental research, short commentary and review articles in this area.

 

Topics include, but not limited to, biomimetic synthesis of MNPs and their bioactivities such as their anticancer, antimicrobial, and antioxidant potentials as well as their roles in drug delivery systems, gene delivery, medicine, cell labeling, biosensors, wound dressings, biocatalysis, biotherapeutics, disease prevention, etc. 


Keywords

Nanobiotechnology, Nanobiomaterials, Biological Synthesis, Metal Nanoparticles, Biological Activity, Molecular and Cellular Mechanisms

Published Papers


  • Open Access

    VIEWPOINT

    Mechanobiology of the cell surface: Probing its remodeling dynamics using membrane tether pulling assays with optical tweezers

    JULIANA SOARES, DOUGLAS G. FREITAS, PEDRO S. LOURENÇO, JEFTE FARIAS, BRUNO PONTES
    BIOCELL, Vol.46, No.9, pp. 2009-2013, 2022, DOI:10.32604/biocell.2022.019969
    (This article belongs to this Special Issue: Molecular and Cellular Nanobiotechnology)
    Abstract Mammalian cell surfaces consist of the plasma membrane supported by an underneath cortical cytoskeleton. Together, these structures can control not only the shape of cells but also a series of cellular functions ranging from migration and division to exocytosis, endocytosis and differentiation. Furthermore, the cell surface is capable of exerting and reacting to mechanical forces. Its viscoelastic properties, especially membrane tension and bending modulus, are fundamental parameters involved in these responses. This viewpoint summarizes our current knowledge on how to measure the viscoelastic properties of cell surfaces employing optical tweezers-based tether assays, paving the way for a better understanding of… More >

  • Open Access

    ARTICLE

    Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

    ABDELKADER HASSANI, SITI ASLINA HUSSAIN, MOTHANNA SADIQ AL-QUBAISI, MOHAMED LAKHDER BELFAR, HAKIM BELKHALFA, HAMID HAMMAD ENEZEI, HAMID ZENTOU, WISAM NABEEL IBRAHIM, ABD ALMONEM DOOLAANEA
    BIOCELL, Vol.46, No.3, pp. 677-687, 2022, DOI:10.32604/biocell.2022.016848
    (This article belongs to this Special Issue: Molecular and Cellular Nanobiotechnology)
    Abstract The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles… More >

  • Open Access

    ARTICLE

    Ameliorative effects of melatonin and zinc oxide nanoparticles treatment against adverse effects of busulfan induced infertility in male albino mice

    AMOURA M. ABOU-EL-NAGA, SHAKER A. MOUSA, FAYEZ ALTHOBAITI, EMAN FAYAD, ENGY S. FAHIM
    BIOCELL, Vol.46, No.2, pp. 535-545, 2022, DOI:10.32604/biocell.2022.017739
    (This article belongs to this Special Issue: Molecular and Cellular Nanobiotechnology)
    Abstract Testicular damage is one of the most hazardous effects as it’s associated with azoospermia. Busulfan (Bu) is a highly toxic chemotherapeutic drug that affects testis. Thirty male Swiss albino mice divided into six groups of 5 animals each. Control (oral 0.9% saline daily for 75 days); Mel (20 mg/kg/day orally for 30 days); ZnO NPs (5 mg/kg/day i.p. for 30 days); BU (single i.p. injection of 40 mg/kg and then left for 45 days); BU + Mel (single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day Mel for 30 days); BU + ZnO NPs… More >

  • Open Access

    VIEWPOINT

    Nanotherapeutics approaches to improve the efficacy of CAR-T cells in solid tumors

    FRANCESCO MAININI
    BIOCELL, Vol.45, No.5, pp. 1171-1173, 2021, DOI:10.32604/biocell.2021.017399
    (This article belongs to this Special Issue: Molecular and Cellular Nanobiotechnology)
    Abstract Adoptive cell therapy and Immune Checkpoint Blockade Inhibitors have recently revolutionized the field of oncology. However, these types of immunotherapeutic approaches have limited success in treating solid tumors. In particular, chimeric antigen receptor (CAR)-T cells efficacy is hampered by immunosuppressive signals in the tumor microenvironment (TME) and by a limited infiltration of re-infused T cells to the tumor site. The field of nanobiotechnology applied to oncology is also rapidly expanding. Nanoparticles-based delivery systems can be employed to modulate the activity of immune cells present in the TME enhancing the efficacy of CAR-T cells. Interestingly, nano-backpacks can be attached to CAR-T… More >

  • Open Access

    ARTICLE

    Zinc oxide nanoparticles and epibrassinolide enhanced growth of tomato via modulating antioxidant activity and photosynthetic performance

    MOHAMMAD FAIZAN, AHMAD FARAZ, SHAMSUL HAYAT, JAVAID A. BHAT, FANGYUAN YU
    BIOCELL, Vol.45, No.4, pp. 1081-1093, 2021, DOI:10.32604/biocell.2021.015363
    (This article belongs to this Special Issue: Molecular and Cellular Nanobiotechnology)
    Abstract Nanotechnology has greatly expanded the applications of nanoparticles (NPs) domain in the scientific field. In this context, the zinc oxide nanoparticles (ZnO-NPs) and 24-epibrassinolide (EBL) has been revealed to positively regulate plant metabolism and growth. In the present study, we investigated the role of ZnO-NPs and EBL in the regulation of plant growth, photosynthetic efficiency, enzymes activities and fruit yield in tomato. Foliar treatment of ZnO-NPs at three levels (10, 50 or 100 ppm) and EBL (10−8 M) were applied separately or in combination to the foliage of plant at 35–39 days after sowing (DAS); and the control plants were… More >

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