Special Issue "Molecular and Cellular Nanobiotechnology"

Submission Deadline: 30 December 2021
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Guest Editors

Dr. Ebrahim Mostafavi, Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; School of Medicine, Stanford University, Stanford, CA, USA.


Dr. Elham Mohit, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: el_mohit@yahoo.com


Dr. Atieh Hashemi Soltanieh, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: at_hashemi@sbmu.ac.ir


Prof. Hossein Vahidi, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: h.vahidi@sbmu.ac.ir


Dr. Hamed Barabadi, Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: barabadi@sbmu.ac.ir

Summary

Nanobiotechnology provides a promising chance to develop new materials and methods that could enhance our fundamental understanding of the interactions of nanomaterials with intracellular structures, the process, and the environment. Significantly, developing biosynthesized nanoparticles for pharmaceutical and biological applications is an important objective in nanobiotechnology. The majority of available research in this line has been focused on biological synthesis of metal nanoparticles (MNPs) such as silver and gold nanoparticles by employing natural resources including natural biomolecules, bacteria, yeasts, fungi, plants, algae, photosynthetic organisms, and marine organisms as greener and more environmentally-friendly processes in comparison to traditional physicochemical routes for MNPs synthesis. The dual role of enzymes and biomolecules as reducing and stabilizing agents for biosynthesis of MNPs has been demonstrated. Biological synthesized MNPs have emerged as new tools that can be used for a wide range of biological activities such as antibacterial, antifungal, antiviral, anticancer, antidiabetic, antiparasitic, and anti-inflammatory activities.

 

This special issue will focus on the novel findings and recent researches and developments in bio-based synthesis of MNPs as emerging bioactive agents from molecular to cellular levels. We invite authors to submit a wide range of manuscripts, including experimental research, short commentary and review articles in this area.

 

Topics include, but not limited to, biomimetic synthesis of MNPs and their bioactivities such as their anticancer, antimicrobial, and antioxidant potentials as well as their roles in drug delivery systems, gene delivery, medicine, cell labeling, biosensors, wound dressings, biocatalysis, biotherapeutics, disease prevention, etc. 


Keywords
Nanobiotechnology, Nanobiomaterials, Biological Synthesis, Metal Nanoparticles, Biological Activity, Molecular and Cellular Mechanisms

Published Papers
  • Nanotherapeutics approaches to improve the efficacy of CAR-T cells in solid tumors
  • Abstract Adoptive cell therapy and Immune Checkpoint Blockade Inhibitors have recently revolutionized the field of oncology. However, these types of immunotherapeutic approaches have limited success in treating solid tumors. In particular, chimeric antigen receptor (CAR)-T cells efficacy is hampered by immunosuppressive signals in the tumor microenvironment (TME) and by a limited infiltration of re-infused T cells to the tumor site. The field of nanobiotechnology applied to oncology is also rapidly expanding. Nanoparticles-based delivery systems can be employed to modulate the activity of immune cells present in the TME enhancing the efficacy of CAR-T cells. Interestingly, nano-backpacks can be attached to CAR-T… More
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