Guest Editors
Dr. Xuemei Zong
Email: xuemei.zong@lsuhs.edu
Affiliation: Institute for Cerebrovascular and Neuroregeneration Research (ICNR), Department of Neurology, Louisiana State University Health Sciences Center, USA
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Research Interests: neurovascular unit, blood-brain barrier dysfunction, cerebral ischemia, chronic cerebral hypoperfusion, neurorepair, neuroinflammation, neurodegeneration, vascular remodeling
Summary
Neurovascular dysfunction is a central feature of both ischemic stroke and neurodegenerative diseases, contributing to neuronal loss, cognitive decline, and long-term disability. Understanding the cellular and molecular mechanisms underlying neurovascular injury and repair is critical for developing effective therapeutic strategies. This Special Issue aims to provide a platform for studies that investigate these processes at the cellular and molecular level, bridging fundamental insights with translational potential.
Key areas of focus include, but are not limited to:
· Cellular and molecular mechanisms of neurovascular dysfunction in ischemic stroke
· Crosstalk between neurons, astrocytes, microglia, and endothelial cells in disease progression
· Blood-brain barrier disruption and repair mechanisms
· Inflammatory, oxidative stress, and apoptotic pathways contributing to neurovascular injury
· Endogenous and stem cell-mediated neurovascular repair processes
· Molecular mechanisms of neurodegeneration and their impact on vascular integrity
· Mechanism-driven approaches for neurovascular remodeling and therapeutic interventions
By focusing on the interplay between cellular players and molecular pathways, this Special Issue seeks to highlight high-quality original research and comprehensive reviews that advance our understanding of neurovascular pathology and repair, ultimately facilitating the translation of mechanistic insights into innovative therapeutic approaches.
Keywords
neurovascular dysfunction, ischemic stroke, neurodegeneration, blood-brain barrier, cellular mechanisms, molecular pathways, neurovascular repair
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