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Frontiers in cancer: tumor microenvironment

Submission Deadline: 31 December 2023 (closed)

Guest Editors

Dr. Yingkun Xu, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. 201815207@mail.sdu.edu.cn
Prof. Guibao Li, School of Basic Medical Sciences, Shandong University, Jinan, China. liguibao@sdu.edu.cn

Summary

Tumor microenvironment (TME) refers to the surrounding microenvironment where tumor cells exist, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules and extracellular matrix. TME is closely related to the occurrence and development of tumors, and they interact continuously. Tumors can affect their microenvironment by releasing cell signaling molecules, promoting tumor angiogenesis and inducing immune tolerance. In contrast, immune cells in TME can affect the growth and development of cancer cells. Furthermore, different components in the TME play critical roles in cellular plasticity. Plasticity is a major feature of the TME's influence on tumor recurrence, leading to reversible transitions between tumorigenic and non-tumorigenic cells.

 

Due to the role of TME, various types of cancers are prone to recurrence, progression, and metastasis. In recent years, with the application and development of technologies such as tumor bulk tissue sequencing and single-cell transcriptome sequencing, the composition of TME has become increasingly clear, and the complex communication network between cells has been fully explored, providing a new perspective for cancer treatment. Since TME is an important potential therapeutic target in cancer treatment, it is necessary to explore the interactions and biological functions of each component in TME to elucidate the detailed mechanism of cancer development.

 

This special issue aims to collate original studies and review articles exploring promising TME-related anti-cancer targets, which can aid in the prevention, diagnosis and treatment of cancer. Potential topics include but are not limited to the following:

 

TME-related biomarkers can be used for the prevention, diagnosis and treatment of cancer

TME-associated biomarkers can influence anti-cancer drug resistance during cancer treatment

TME-associated biomarkers can be used to determine cancer pathogenesis

Signaling mechanism and interaction among TME components

Exploring the potential role of the TME in cancer progression using genomics approaches and biological models


Keywords

TME; cancer research; cancer recurrence; precision medicine; cell signaling

Published Papers


  • Open Access

    ARTICLE

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

    QIOU GU, CHUILIN LAI, XIAO GUAN, JING ZHU, TIAN ZHAN, JIANPING ZHANG
    BIOCELL, DOI:10.32604/biocell.2023.028336
    (This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
    Abstract Objectives: Colorectal cancer (CRC) is a serious threat to human health worldwide. Oxaliplatin is a platinum analog and is widely used to treat CRC. However, resistance to oxaliplatin restricts its effectiveness and application while its target recognition and mechanism of action also remain unclear. Therefore, we aimed to develop an oxaliplatin-resistant prognostic model to clarify these aspects. Methods: We first obtained oxaliplatin-resistant and parental cell lines, and identified oxaliplatin-resistant genes using RNA sequencing (RNA-seq) and differential gene analysis. We then acquired relevant data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Cox regression and Least Absolute… More >

    Graphic Abstract

    A novel oxaliplatin-resistant gene signatures predicting survival of patients in colorectal cancer

  • Open Access

    ARTICLE

    Regulation of RNA methylation and immune infiltration patterns by m5C regulators in head and neck squamous cell carcinoma

    SHIDA HOU, TIANJUN LAN, YAOCHENG YANG, PEISHENG LIANG, XIN LIU, JUNJIE WANG, ZHIFENG CHEN, RONGSHENG ZENG, ZIJING HUANG
    BIOCELL, Vol.47, No.12, pp. 2641-2660, 2023, DOI:10.32604/biocell.2023.043291
    (This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
    Abstract Background: 5-Methylcytosine (m5C) methylation contributes to the development and progression of various malignant tumors. This study aimed to explore the potential role of m5C methylation regulators (m5CMRs) in head and neck squamous cell carcinoma (HNSCC). Methods: The transcription data of HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Subsequently, the m5C patterns in HNSCC were evaluated based on 14 m5CMRs. Then, the m5Cscore was developed to quantify m5C patterns by using principal component analysis (PCA) algorithms. Two single-cell RNA sequencing datasets and various methods were employed to assess the prognostic value… More >

  • Open Access

    ARTICLE

    Identification of an immune classifier for predicting the prognosis and therapeutic response in triple-negative breast cancer

    KUAILU LIN, QIANYU GU, XIXI LAI
    BIOCELL, Vol.47, No.12, pp. 2681-2696, 2023, DOI:10.32604/biocell.2023.043298
    (This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
    Abstract Objectives: Triple-negative breast cancer (TNBC) poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior. Methods: We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA. Utilizing weighted gene coexpression network analysis, we pinpointed 34 TNBC immune genes linked to survival. The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction. We calculated chemotherapy sensitivity scores using the “pRRophetic” package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and… More >

  • Open Access

    ARTICLE

    Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation

    ZIPENG LIN, CHUXI TANG, LE KANG, GUANXI LAI, SHIWEN LIU, YIXIANG WU, HUIQUN TIAN, SONG LIU
    BIOCELL, Vol.47, No.10, pp. 2217-2232, 2023, DOI:10.32604/biocell.2023.030233
    (This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
    Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. In this review, we found that the TIPE family showed highly homologous sequences and conserved functional domains, such as the death effector domain (DED)-like domain but displayed different roles and mechanisms in different biological activities. For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. TIPE2 has multiple roles in tumor progression regulation, and antitumor drug… More >

    Graphic Abstract

    Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation

  • Open Access

    REVIEW

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

    ELYN AMIELA SALLEH, YEONG YEH LEE, ANDEE DZULKARNAEN ZAKARIA, NUR ASYILLA CHE JALIL, MARAHAINI MUSA
    BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541
    (This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
    Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient… More >

    Graphic Abstract

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

  • Open Access

    HOXB8 contributed to oxaliplatin chemo-resistance in colon cancer cells by activating STAT3

    LIANLI NI, YUN YU, HAN LIN, WEISHAN ZHUGE, LU TAO, YIWEI SHEN, RI CUI, SHAOTANG LI
    BIOCELL, Vol.47, No.10, pp. 2245-2254, 2023, DOI:10.32604/biocell.2023.030147
    (This article belongs to this Special Issue: Frontiers in cancer: tumor microenvironment)
    Abstract Background: Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. Methods: The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC… More >

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