Guest Editors
Prof. Haojie Huang
Email: hhuanghaojie@163.com
Affiliation: Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China
Homepage:
Research Interests: pancreatitis, inflammation, pancreatic cancer, single-cell sequencing, digestive endoscopy
Prof. Zhendong Jin
Email: zhendongjin@163.com
Affiliation: Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China
Homepage:
Research Interests: gallstone, pancreatic cancer, inflammation, endoscopic ultrasound, reactive oxygen species
Summary
Digestive diseases represent a broad spectrum of disorders with complex etiologies involving dysregulated cellular functions and aberrant molecular signaling. While clinical manifestations and tissue-level alterations are well documented, a comprehensive understanding of these diseases requires in-depth investigation at the cellular and subcellular levels, where disease initiation and progression are fundamentally driven. In line with the scope of BIOCELL, this Special Issue aims to provide a dedicated platform for studies that elucidate the cellular and molecular mechanisms underlying digestive diseases, with an emphasis on mechanistic insight rather than descriptive or purely clinical observations.
This Special Issue focuses on original research that dissects how molecular regulators, signaling pathways, and intracellular processes govern cellular behavior in digestive system disorders. Contributions are expected to be grounded in cell-based experimental evidence, including molecular and biochemical analyses that establish causal relationships between specific molecules, signaling cascades, and cellular phenotypes. Studies incorporating animal models or clinical samples are welcome only when they serve to validate mechanistic findings initially uncovered at the cellular level.
Key areas of focus include, but are not limited to:
· Cellular and subcellular mechanisms driving the onset and progression of digestive diseases
· Molecular signaling pathways regulating inflammation, metabolism, stress responses, and cell fate in digestive system cells
· Alterations in cellular behaviors such as proliferation, apoptosis, autophagy, differentiation, migration, and epithelial–mesenchymal transition
· Cell-type–specific functions and interactions within the digestive microenvironment, including epithelial, immune, and stromal cells
· Mechanistic studies of molecular targets and intracellular pathways involved in digestive disease–related therapeutic responses
· Cell-based validation of pharmacological or genetic interventions targeting key signaling molecules
· Integration of in vitro cellular models with in vivo evidence to confirm biological relevance of identified mechanisms
By emphasizing mechanistic rigor, causal validation, and molecular pathway analysis at the cellular level, this Special Issue seeks to advance fundamental understanding of digestive diseases and to highlight biologically meaningful targets that may inform future therapeutic strategies, while remaining firmly rooted in BIOCELL's focus on cellular and molecular biology.
Keywords
cellular mechanisms, molecular signaling, digestive diseases, cell-based models, intracellular pathways, therapeutic targets, disease pathogenesis
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