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Open Access

ARTICLE

Antiglycation, Antioxidant, and Antidiabetic Effects of Ibervillea sonorae (Wereke) in a Diabetic Zebrafish Model

Leonardo Daniel Villalana Alvarez1, Abraham Heriberto García-Campoy2, Alethia Muñiz-Ramirez3,*
1 División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, Camino a la Presa San José 2055, Col. Lomas 4 Sección, San Luis Potosí, México
2 Universidad Intercultural de San Luis Potosí (UICSLP), Unidad Académica Villa de Reyes, Avenida Universidad No. 29, Col La Paz, San Luis Potosí, México
3 División de Materiales Avanzados, Instituto Potosino de Investigación Científica y Tecnológica-SECIHTI, Camino a la Presa San José 2055, Col. Lomas 4 Sección, San Luis Potosí, México
* Corresponding Author: Alethia Muñiz-Ramirez. Email: email
(This article belongs to the Special Issue: Bioactive Natural Products from Medicinal Plants: Phytochemical and Pharmacological Studies)

Phyton-International Journal of Experimental Botany https://doi.org/10.32604/phyton.2026.085201

Received 07 May 2026; Accepted 06 July 2026; Published online 20 July 2026

Abstract

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, oxidative stress, and the formation of advanced glycation end products (AGEs). This study examined the antiglycation, antioxidant, and antidiabetic properties of the methanolic extract of Ibervillea sonorae (IsM). Antiglycation activity was assessed in vitro using a bovine serum albumin–glucose model, and the antidiabetic effects were evaluated using a zebrafish model of experimentally induced hyperglycemia. Gas chromatography–mass spectrometry (GC–MS) analysis revealed several metabolites, including fatty acids and phytosterols. The extract significantly inhibited AGEs formation in vitro and reduced AGEs accumulation in the ocular tissue of diabetic zebrafish. In vivo treatment significantly decreased blood glucose, triglyceride, and cholesterol levels compared to diabetic controls. IsM also modulated oxidative stress by increasing reduced glutathione (GSH) levels and the activity of antioxidant enzymes (GPx, SOD, and CAT), while decreasing malondialdehyde levels in blood and gill tissues. These results suggest that the extract has protective effects through modulation of oxidative stress and inhibition of protein glycation. While these results demonstrate the therapeutic potential of Ibervillea sonorae, additional research is necessary to isolate the bioactive compounds and elucidate the molecular mechanisms underlying the observed biological effects.

Graphical Abstract

Antiglycation, Antioxidant, and Antidiabetic Effects of <i>Ibervillea sonorae</i> (Wereke) in a Diabetic Zebrafish Model

Keywords

Diabetes mellitus; oxidative stress; zebrafish model; advanced glycation end products; phytochemicals; Wereke

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