Guest Editor(s)
Dr. Haoling Zhang
Email: zhanghaolingedu@163.com
Affiliation: Department of Biomedical Sciences, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia, Kepala Batas, Malaysia
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Research Interests: cell death, ATP-induced cell death, tumor immunology, degenerative diseases, high-altitude diseases, cancer biology, inflammation; molecular mechanisms
Assoc. Prof. Dr. Doblin Sandai
Email: doblin@usm.my
Affiliation: Department of Biomedical Sciences, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia, Kepala Batas, Malaysia
Homepage:
Research Interests: medical mycology, host–pathogen interaction; tumor immunology, microbiota, cancer biology, inflammation, cell death, molecular mechanisms
Dr. Wangzheqi Zhang
Email: zwzq001031@smmu.edu.cn
Affiliation: Department of Anesthesiology, Naval Medical University, Shanghai, China
Homepage:
Research Interests: cell death mechanisms, ferroptosis, pyroptosis, tumor immunology, sepsis, inflammation, protein post-translational modifications, precision medicine
Dr. Mowaffaq Adam Ahmed Adam
Email: amowaffaq@gmail.com
Affiliation: Office of Continuing Education, Suffolk County Community College, New York, USA
Homepage:
Research Interests: cancer biology, molecular biology, cell death, tumor metabolism, microbiology, mycotoxins, inflammation, translational medicine
Summary
Regulated cell death is a fundamental biological process that plays a crucial role in maintaining cellular homeostasis and contributing to the development and progression of various diseases. Recent studies have revealed the diversity of cell death modalities, including apoptosis, ferroptosis, pyroptosis, and necroptosis, which are governed by complex molecular mechanisms and tightly regulated networks.
This Themed Collection aims to systematically summarize recent advances in the molecular mechanisms, regulatory patterns, and therapeutic implications of cell death. It will also summarize the functional roles of cell death under different pathological conditions and their potential regulatory mechanisms. In addition, particular attention will be given to the crosstalk among different cell death pathways, as well as their interactions with immune responses, metabolic processes, and microenvironmental factors.
Furthermore, this collection will explore translational perspectives, including therapeutic strategies targeting cell death pathways, mechanisms of drug resistance, and applications in precision medicine. We welcome original research articles, reviews, and perspectives that provide innovative and cutting-edge insights, with the goal of promoting the translation of basic research into clinical practice.
Keywords
cell death, apoptosis, ferroptosis, pyroptosis, necroptosis, molecular mechanisms, therapeutic targets, precision medicine
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