Guest Editors
Dr. Udayakumar Karunakaran
Email: udayactech@gmail.com
Affiliation: Institute of Medical Science, Yeungnam University College of Medicine, Daegu 42415, Republic of Korea
Homepage:
Research Interests: cellular signaling, polyamine metabolism, mitochondrial metabolism, redox biology, diabetes, antioxidant system, H2S biology, endocrine-disrupting chemicals
Dr Elumalai Suma
Email: Ussuma30@gmail.com
Affiliation: Institute of Medical Science, Yeungnam University College of Medicine, Daegu 42415, Republic of Korea
Homepage:
Research Interests: cellular signaling, metabolism, ferroptosis, oxidative stress, reactive oxygen species
Summary
Cellular senescence and stress signaling are fundamental biological processes that play dual roles in maintaining homeostasis and contributing to disease pathogenesis. In recent years, accumulating evidence has revealed that dysregulated cell signaling and senescence are central to aging-related diseases, cancer, metabolic dysfunction, and neurodegeneration.
This Special Issue of BIOCELL aims to bring together cutting-edge research that explores how cellular stress responses and signaling networks regulate senescence and influence health and disease states. We are particularly interested in studies that elucidate the underlying molecular and cellular mechanisms and identify potential therapeutic targets that could mitigate pathological consequences or enhance tissue regeneration.
We welcome original research articles, reviews, and short communications that cover, but are not limited to, the following topics:
-Mechanisms of cellular senescence and its regulation by stress signaling pathways
-Crosstalk between senescence, inflammation, and immune responses (e.g., SASP, inflammaging)
-Role of mitochondria, proteostasis, autophagy, and metabolism in senescence
-Cell signaling in age-associated diseases, including cancer, neurodegenerative, and metabolic disorders
-Molecular strategies to selectively target senescent cells (senolytics, senomorphics)
-Novel biomarkers and imaging techniques for identifying cellular senescence
-Therapeutic approaches to modulate stress responses and delay cellular aging
This Special Issue provides an interdisciplinary platform for researchers working at the interface of cell biology, molecular medicine, and therapeutic development. Through a comprehensive examination of the signaling networks and senescence pathways, we hope to inspire new insights into cellular plasticity, resilience, and therapeutic innovation.
Keywords
cellular senescence, stress signaling, cell signaling networks, aging, inflammation, SASP, autophagy, mitochondrial dysfunction, therapeutic targets, age-related diseases, cancer, neurodegeneration, metabolic disorders, senolytics, senescence biomarkers
Login
Register
Submit a Paper
Propose a Special lssue