Guest Editor(s)
Dr. Zhijia Xia
Email: zhijia_xia@yeah.net
Affiliation: Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany
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Research Interests: epidemiology, hepatology, liver fibrosis, hepatocellular carcinoma, tumor immunology, bioinformatics, molecular mechanisms
Summary
Disease initiation and progression are driven by dysregulated cellular signaling networks that control inflammation, immune responses, metabolism, cell death, tissue remodeling, and therapeutic resistance. Despite advances in molecular medicine and precision therapy, many diseases remain difficult to prevent or treat due to cellular heterogeneity, adaptive signaling rewiring, and complex tissue microenvironmental interactions.
Multiple signaling networks, including PI3K/AKT/mTOR, MAPK/ERK, JAK/STAT, TGF-β, NF-κB, Wnt/β-catenin, Hippo/YAP, Notch, Hedgehog, NLRP3 inflammasome, cGAS–STING, and oxidative stress-related pathways, have been found to play crucial roles in cancer, inflammatory diseases, autoimmune disorders, cardiovascular diseases, metabolic diseases, neurodegenerative diseases, fibrotic diseases, and infectious diseases.
This Collection aims to bring together original research articles, reviews, and translational studies to advance mechanistic understanding, biomarker discovery, and the development of more effective diagnostic and therapeutic strategies for diverse human diseases. We welcome articles addressing, but not limited to, the following themes:
1. Inflammation- and immune-related signaling pathways in disease initiation and progression
2. Metabolic reprogramming, oxidative stress, and stress-response signaling in pathological processes
3. Cell death-related signaling pathways, including apoptosis, ferroptosis, pyroptosis, autophagy, and senescence
4. Fibrosis, tissue remodeling, extracellular matrix remodeling, and regeneration-associated signaling networks
5. Bioinformatics-driven discovery of novel cell–cell communication networks and key signaling molecules
6. Genetic variation and epigenetic alterations influencing disease susceptibility, progression, and therapeutic response
Keywords
disease initiation, disease progression, cellular signaling pathways, inflammation, immune regulation, therapeutic resistance
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