Guest Editors
Dr. Pasquale Picone
Email: Pasquale.picone@irib.cnr.it
Affiliation: Institute for Biomedical Research and Innovation, National Research Council (CNR), 90146 Palermo (PA), Italy
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Research Interests: neuroscience, nanotechnology, mitochondrial transplantation, brain drug delivery
Dr. Laura Palumbo
Email: laura.palumbo@irib.cnr.it
Affiliation: Institute for Biomedical Research and Innovation, National Research Council (CNR), 90146 Palermo (PA), Italy
Homepage:
Research Interests: neurological diseases, neuroinflammation, mitochondrial dysfunction, inflammasomes, glial cell activation, blood-brain barrier dysfunction
Summary
Neuroinflammation is a critical driver of pathology in a wide range of central nervous system (CNS) diseases, from chronic neurodegenerative conditions to acute neurological insults. Among the key players involved, glial cells and inflammasome signaling pathways have emerged as pivotal modulators of neuroinflammatory processes, contributing both to disease progression and to potential mechanisms of resilience. This special issue aims to explore the dynamic interplay between neuroinflammatory responses and neuroprotective strategies across diverse CNS pathologies, with a focus on uncovering underlying mechanisms and identifying potential therapeutic targets.
This issue welcomes original research and reviews that span basic mechanistic studies, preclinical models, and translational perspectives. We are particularly interested in contributions that address:
1. Neurodegenerative Diseases: Investigations into how chronic inflammation contributes to the progression of Alzheimer's disease, Parkinson's disease, Huntington's disease, and other neurodegenerative disorders.
2. Epilepsy and Seizure Disorders: Studies on how neuroinflammatory and excitotoxic cascades influence seizure susceptibility and epileptogenesis.
3. Multiple Sclerosis and Demyelinating Conditions: Insights into immune-mediated neuroinflammation, glial cell dysfunction, and remyelination strategies.
4. Acute CNS Injury and Stroke: Mechanistic and therapeutic research on ischemia-induced inflammation, BBB disruption, and neuroprotective interventions.
5. Oxidative Stress and Cellular Stress Responses: Molecular pathways connecting inflammation, redox imbalance, and neuronal vulnerability.
6. Therapeutic Development: Preclinical and in vitro studies testing anti-inflammatory or neuroprotective compounds, biologics, or gene therapies with translational potential.
By integrating findings from molecular, cellular, and systemic levels, this issue aims to advance our understanding of how inflammation and neuroprotection intersect, ultimately guiding the development of more effective CNS therapeutics.
Keywords
neuroinflammation, neuroprotection, CNS diseases, neurodegeneration, epilepsy, multiple sclerosis, excitotoxicity, therapeutic targets, Inflammasomes, gliosis.
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