Guest Editor(s)
Prof. Dr. Nongyue He
Email: nyhe1958@163.com
Affiliation: School of Biological and Medical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China
Homepage:
Research Interests: biochips, biosensors, functional nanomaterials, biomedical applications, nucleic acid detection, nanobiotechnology, diagnostic technologies, biosensing
Assoc. Prof. Dr. Guang Yang
Email: yakoaka@foxmail.com
Affiliation: Division of Renal Medicine, Peking University Shenzhen Hospital, Peking University, Shenzhen, China
Homepage:
Research Interests: inflammation, regeneration, kidney, cardiovascular
Summary
Recent advances in molecular and cellular biology have demonstrated that nucleic acid-mediated regulation plays a central role in diverse biological processes and disease progression. Coding and non-coding nucleic acids, including messenger RNAs (mRNAs), microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and other regulatory nucleic acids, have emerged as critical modulators of gene expression, intracellular signaling pathways, cellular differentiation, apoptosis, proliferation, metabolism, and immune responses. Understanding the molecular mechanisms and disease-associated cellular phenotypes by which these regulatory molecules influence cellular functions has become a major focus in modern biomedical research.
This Special Issue aims to provide an interdisciplinary platform for high-quality studies that investigate the molecular mechanisms underlying nucleic acid regulation in cellular function and disease. Particular emphasis will be placed on mechanistic studies involving molecular targets, signaling pathways, functional validation, and causal relationships within cellular systems. Studies integrating pathway analysis, gene regulation, target validation, cellular functional assays, and disease-related molecular mechanisms are particularly encouraged.
Research focusing on how nucleic acid-mediated regulation affects cell–cell communication, intracellular signaling networks, cellular stress responses, and disease progression will be particularly welcomed.
To broaden the scope while maintaining alignment with BIOCELL's aims, this Special Issue also welcomes studies in which advanced molecular analytical approaches—including molecular detection technologies, biosensing strategies, aptamer-based recognition, and multi-omics analyses—are employed to uncover or validate cellular and molecular mechanisms. These analytical approaches are expected to serve as supportive tools for biological discovery and mechanistic investigation, rather than focusing solely on methodological innovation or platform development.
Potential topics include, but are not limited to:
• Gene regulation and nucleic acid-mediated cellular functions
• Molecular targets and signaling pathway regulation
• miRNA, lncRNA, circRNA and epigenetic regulation
• Nucleic acid-mediated regulation of extracellular vesicles and intercellular communication
• RNA-based regulation of tumor microenvironment and disease-associated cellular processes
• Aptamer-assisted molecular investigation and target validation
• Biosensing and molecular detection approaches supporting cellular and molecular mechanism studies
This Special Issue is expected to bring together researchers from molecular biology, cell biology, genetics, translational medicine, cancer biology, immunology, bioengineering and related disciplines, providing new insights into nucleic acid regulation and molecular mechanisms underlying health and disease.
Keywords
nucleic acid regulation, molecular mechanisms, cell signaling, gene regulation, miRNA, lncRNA, cellular function, target validation, signal transduction, molecular biomarkers, functional genomics, disease mechanisms
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