Guest Editors
Dr. Camelia Munteanu
Email: camelia.munteanu@usamvcluj.ro
Affiliation: Biology Section, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania
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Research Interests: cancer, obesity, nutrition, metabolism, lncRNA, vitamins
Dr. Alessandra Ferraresi
Email: alessandra.ferraresi@med.uniupo.it
Affiliation: Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", Via P. Solaroli 17-28100 Novara, Italy
Homepage:
Research Interests: cancer, autophagy, metabolism, nutraceuticals, nanomedicine
Summary
Obesity is a major global health challenge, significantly increasing the risk of various cancers, including breast, colorectal, liver, and pancreatic cancers. Despite the growing epidemiological evidence linking obesity to cancer development and progression, the underlying cellular and molecular mechanisms remain incompletely understood. Elucidating how obesity-driven alterations at the cellular level influence tumorigenesis is crucial for identifying novel biomarkers and therapeutic targets.
This special issue aims to bring together cutting-edge research exploring the intricate relationship between obesity and cancer, focusing on the molecular and cellular processes that mediate this connection. We invite original research articles and comprehensive reviews that delve into the mechanistic understanding of how obesity-induced metabolic dysregulation, inflammation, and microenvironmental changes contribute to cancer initiation, progression, and therapeutic resistance.
Topics of Interest:
1. Cellular Signaling Pathways Linking Obesity and Cancer
· The role of obesity-driven metabolic alterations in cancer cell proliferation and metastasis
· Dysregulation of key signaling pathways (e.g., PI3K/AKT, mTOR, AMPK) in the obesity-cancer axis
2. Obesity-Induced Tumor Microenvironment (TME) Remodeling
· Adipose tissue remodeling and its impact on the tumor microenvironment
· The influence of obesity-associated inflammatory cytokines (e.g., IL-6, TNF-) on immune evasion
3. Lipid Metabolism, Cellular Stress, and Tumorigenesis
· Lipid metabolic reprogramming as a driver of obesity-associated cancers
· Mitochondrial dysfunction and oxidative stress in the obesity-cancer connection
4. Advanced Approaches to Deciphering the Obesity-Cancer Nexus
· Single-cell and multi-omics analyses to uncover cellular heterogeneity in obesity-related cancers
· Integrative systems biology approaches to identify obesity-related oncogenic networks
5. Therapeutic Innovations and Precision Medicine
· Targeting obesity-associated metabolic pathways for cancer prevention and treatment
· Novel therapeutic interventions addressing obesity-induced tumorigenesis
This special issue aims to deepen our understanding of the molecular and cellular underpinnings of the obesity-cancer nexus. By highlighting innovative research in this area, we seek to foster interdisciplinary collaboration and pave the way for new therapeutic strategies to mitigate obesity-associated cancer risks. Contributions to this issue will advance knowledge at the intersection of obesity, cancer biology, and molecular medicine, offering insights with both scientific and clinical implications.
We welcome submissions from a broad range of disciplines, including cell biology, molecular oncology, metabolism, and translational medicine. Through this special issue, we hope to provide a comprehensive platform for exploring the complex interplay between obesity and cancer at the cellular level.
Keywords
obesity-cancer nexus, cellular signaling pathways, tumor microenvironment, metabolic reprogramming, inflammation and tumorigenesis, lipid metabolism, molecular and cellular mechanisms, therapeutic targets
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